Haplotype, Haplotype Blocks, and Linkage Disequilibrium

Question 1

Genetic markers showing linkage with each other are always….

Answer 1

syntenic

“Genes that lie on the same chromosome” - Google

Question 2

What is a haplotype?

Answer 2

the possible allelic combinations on a single
chromosome

Question 3

When the chromosomal region containing a certain gene si studied in detail, it was found taht a mutated allele of this gene is found to be associated with a much smaller set of haplotype background than expected by chance alone. This observation is called…..

Answer 3

linkage disequilibrium

Question 4

In performing linkage disequilibrium mapping of a trait, which one of the following factors is least likely to result in failure of the study?
A. High new mutation rate for the trait
B. Lack of participation by family members of affected individuals
C. Poor definition of phenotype
D Population admixture
E. Small sample size of affected individuals

Answer 4

B. Lack of participation by family members of affected individuals

Question 5

A SNP Array study shows that the genome of a patient is homozygous at ~7% of loci. Which of hte following is the most likely interpretation concerning the patient?

Answer 5

His parents are first cousins.