Disorders of FGF and RAS signaling

Question 1

Patients with Crouzon syndrome have activating mutations of the fibroblast growth factor receptor 2 (FGFR2). This means that…

Answer 1

the receptor no longer requires growth factor stimulation in order to elicit the cascade of signaling responses that normally would have required growth factor stimulation to take place

Question 2

Activating mutations of fibroblast growth factor receptors tend to involve the cysteine residues. This results in:
A. failure for ligands to bind to the receptor
B. nonsense mediated decay of nascent receptor molecules
C. the increased propensity for lysosomal targeting of hte receptors
D. the increased propensity for disulfid bond formation between otherwise monovalent receptors
E. the increased propensity for misfolding of receptor molecules

Answer 2

D. the increased propensity for disulfid bond formation between otherwise monovalent receptors