Haloperidol/ Haldol

Question 0

Mechanism of Action

Answer 0

Mesolimbic D1/D2 antagonist> depresses release of hypothalmic and hypophyseal hormones, depresses the reticular activating system, thus affecting basal metabolism, body temp, wakefulness, vasomotor tone, and emesis

Question 1

Drug Class

Answer 1

Butyrophenone Antipsychotic/ Neuroleptic

Question 2

Pharmacokinetics

Answer 2

Onset - 30-45min
Peak - 10-20min
Duration - Varies
Half life - 3-35hrs

Question 3

Indications

Answer 3

Acute psychotic espisode

Question 4

Contraindications

Answer 4

CNS depression

Agitation secondary to shock or hypoxia

Question 5

Side effects

Answer 5

EPS, insomnia, restlessness, drowsiness, seizures, dry mouth, constipation, respiratory depression, tachycardia, hypotension, prolonged QT syndrome, torsades

Question 6

Dose

Answer 6

Adult- 5mg IM q 4-8hr PRN

PEDI- 1-3mg IM q 4-8hr PRN max 0.15 mg/kg/day

Question 7

Precautions

Answer 7

May impair physical and mental abilities, may cause orthostatic hypotension, may cause EPS or dystonic reactions

Question 8

Drug-Drug

Answer 8

Caution in pts taking Lithium, may cause encephalopathic syndrome ( irreversible brain damage)
May increase chance of hypotension when taken with antihypertensives
Additive effects with depressants and other antipsychotics- increased CNS depression