Hailey-Hailey and Dariers Flashcards
Pathogenesis of Darier disease
Clinical features of Darier disease
1) peak onset in puberty
2) primary lesions - red brown keratotic crusted papule in a seborrheic distribution (trunk, scalp, face, lateral necl)
3) Can coalesce to form papillomatous masses
4) Small hypopigmented macules mixed with keratotic papules
5) Occasionally vesicles can ocxur - if prominent exclude herpes infection (kaposi varicelliform eruption)
6) Intertriginous lesions in most patients (axilla, groin, infra-mammary, can confuse with hailey hailey)
7) can become macerated with fungating masses and malodor
8) Brown flat-topped papules om dorsal hands/feet - resembles plane warts
9) acral haemorrhagic vesicles
10) Keratotic palmoplantar papules/depressions
11) Nail change
- wedge shaped subungual hyperkeratosis
-V-shaped notches
-longitudinal ridging
-longitudinal white/red lines
-brittle
12) painless white papules/ruggose plaques (hard palate, buccal muccosa, gingiva)
Symptoms of Dariers
Modifying factors of dariers
Course of disease (Dariers)
Complications of Darier disease
Subtypes of Dariers disease
Pathology of Darier disease
Differential diagnosis of darier disease
Treatment of darier disease
Pathogenesis of Hailey-Hailey disease
Clinical features od Hailey Hailey disease
Symptoms of Haile Hailey
Modifying factors in Hailey Hailey disease
Course of disease (Hailey Hailey)
Complications of HHD
pathology of HHD
Treatment of HHD
Dermoscopy of Hailey Hailey disease and Dariers
Describe naltrexone in the management of HHD and DD
Describe Grovers disease (clinical an dpathogenesis)
Describe histology of Grovers disease
Describe treatmenr of Grovers disease
