haemostasis

Question 1

what platelet receptors help adhere ?

Answer 1

GP1b

GP1a

Question 2

what platelet factors help activate ?

Answer 2

ADP receptor

COX enzyme

Question 3

what makes platelets aggregate ?

Answer 3

thromboxane A2

Question 4

what causes platelet coagulation ?

Answer 4

scramblase

Question 5

what is the intrinsic pathway ?

Answer 5

1. factor 12
2. factor 11
3. factor 9
4. factor 8
5. factor 10
6. prothrombin - thrombin
7. fibrinogen - fibrin

Question 6

what is the extrinsic pathway ?

Answer 6

1. factor 7 + tissue factor
2. factor 10
3. prothrombin - thrombin
4. fibrinogen - fibrin

Question 7

what effect does thrombin have on the intrinsic pathway ?

Answer 7

inhibits the pathway by negative feedback

Question 8

what are natural anticoagulants and how do they work ?

Answer 8

TFPI - inhibit factors 7a, 10a
proteins C + S - inhibit factor 5a, 8a
antithrombin - inhibits thrombin, 11a, 9a, 8a, 10a

Question 9

what mediates fibrinolysis and how does it occur ?

Answer 9

plasminogen forms plasmin which breaks down fibrin clots

activated by t-PA, u-PA

Question 10

what inhibits plasminogen and plasmin ?

Answer 10

plasminogen - PAI-1, PAI-2

plasmin - a1 antiplasmin, a2macroglobulin

Question 11

what drugs act on platelet ADP receptors ?

Answer 11

clopidogrel
prasugrel
ticagrelor

Question 12

what drugs act on platelet GP 2b/3a ?

Answer 12

abcixiban
tirofiban
eptifibatide

Question 13

what drugs act on platelet COX enzyme ?

Answer 13

aspirin

Question 14

what does warfarin act on ?

Answer 14

factor 9
factor 10
factor 7
prothrombin

Question 15

what does heparin act on ?

Answer 15

factor 10a

thrombin

Question 16

what does rivaroxiban, edoxaban, apixiban work on ?

Answer 16

factor 10a

Question 17

what does dabigatran, argatroban work on ?

Answer 17

thrombin