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Y2 MCD - Haem > Haemostasis > Flashcards

Haemostasis Flashcards

1
Q

What is haemostasis

A

Cellular and biochemical processes that enables both specific and regulated cessation of bleeding in response to vascular insult

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2
Q

What is haemostasis for?

A

Slide 3

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3
Q

Haemostasis is a balance between bleeding and thrombosis

A

CLOZE

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4
Q

Outline the formation of a haemostatic plug

A

Slide 10

PRIMARY HAEMOSTASIS = formation of an unstable platelet plug

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5
Q

What are the characteristics of platelets

A

Slide 16

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6
Q

What do megakaryocytes look like?

A

Slide 17 [pic]

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7
Q

Describe the formation and maturation of platelets from megakaryocytes

A

Slide 18

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8
Q

What are the ultrastructural features of platelets

A

Slide 20

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9
Q

The platelet cytoskeleton is important for…?

A

Slide 21

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10
Q

Describe the process of platelet adhesion

A

Slides 21-31

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11
Q

Describe the process of platelet activation

A

Slides 32-34

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12
Q

Describe the process of aggregation of platelets

A

Slides 34-36

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13
Q

Platelet activation enhances…?

A

Coagulation
CLOZE

Slide 37

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14
Q

The platelet shape changes upon adhesion, activation and aggregation. Describe these shape changes

A

Slide 38

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15
Q

What are the characteristics of ITP?

A

Slide 44

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16
Q

Outline the tissue factor pathway

17
Q

What is the primary site of synthesis of haemostatic proteins?

A

LIver

Slide 50

18
Q

Clotting factors circulate as inactive precursors

19
Q

What clottingg factors are serine protease domain-containing proteins?

20
Q

Describe the initation of coagulation

A

Slide 54, 61-2

Gla domain = allows clotting factors to interact

21
Q

What is tissue factor?

22
Q

What ist he structure of coagulation serine protease proteins?

23
Q

Describe the propagation of coagulation

A

Slide 63-67

When a small amount of thrombin is produced = positive feedback cycle

24
Q

Patients deficient in procoagulant factors can develop haemophilia

25
Q

TURE OR FALSE:

Haemophilia A and B are X-linked

A

TRUE

Slide 67

26
Q

Coagulation is controlled by…?

A 
Slide 75 (only small amount of TFPI)
Slide 76 (Protein C pathway)

Slide 90
Slide 94

27
Q

Describe protein C activation

A

Slide 79-84

28
Q

What is antithrombin?

29
Q

What does heparin do?

A

Binds to antithrombin to enhance efficiency (cofactor)

30
Q

Deficiencies of anttithrombin, protein C and protein S are important ris factors for thrombosis

31
Q

Describe the process of fibrinolysis

A

Slide 97-99

32
Q

Clinical haemostasis

A

DOAC = direct oral anticoagulant

Slide 100

33
Q

Tests for clinical haemostasis

Y2 MCD - Haem (5 decks)

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