Disorders Of Haemostasis Flashcards
What are the elements of a significant bleeding history
Slide 7
Abnormal haemostasis can be caused by…?
Slide 10
Disoders of primar haemostasis
Slide 25
Platelet disorders
Slide 20
ITP is a very commoncause of thrombocytopenia
CLOZE
Slide 16
What are the mechanisms and causes of thrombocytopenia?
Slide 17
Give 3 examples of hereditary platelet defects
Slide 19
Von Willebrand factor disorders
Often hereditary - most common bleeding disorder autosomal Slide 21-22 Type 1 - not enough, but some Type 2 - not working properly Type 3 - not at all, recessive
What are the two main fuctions of VWF in haemostasis?
Slide 22
Vessel wall disorders
Slide 24
What is the bleeding like in disorders of primary haemostasis?
Slide 28
What are the tests for disorders of primary haemostasis?
Slide 30
Deficiency of any coagulatino factor results in a failure of thrombin generation and hence fibrin formation
CLOZE
TRUE OR FALSE:
A primary platelet plug is sufficient for all vessel injuries
False
SLIDE 35
What is haemophilia?
Failure to generate fibrin to stabilise platelet plug
What are the disorders of coagulation?
Slide 43
TRUEOR FALSE:
Coagulation factor deficiencies are not all the same
TRUE
Slide 40
Acquired coagulation disorders are more common in…?
Hospital practice
Slide 42
NOTE: much more common than haemophilia
What happens in ncreased consumption (disorder f coagulation)
Slide 44
DIC = seen with sepsis, amaor tissue damage, cancerUnregulated turning on of coagulation system - starts using all coagulation factors
What is bleeding like in coagulation disorders?
Slide 45
Describe the clinical distinction between bleeding due to platelelt and coagulation defects
Slide 49
Haemarthrosis is the hallmark of haemophilia
CLOZE
What are the tests for coagulation disorders?
Slide 50
APTT = factors XII, Xi, VIII, IX, V, X, II
PT = factors VIIa, V, X, II
Slide 51
Give examples of clotting disorders that are not detected by routine clotting tests
Slide 52
What are the different disorders of fibrinolysis?
Slide 54
What are the genetics of haemophilia?
Sex linked recessive (SLR)
What are the genetics of Von Willebrand disease?
Autosomal
Slide 58
Apart from haemophilia and Von Willebrand disease, bleeding disorders are autosomal recessive (AR) - and therefore much less common
CLOZE
Outline the treatment of abnormal haemostasis
Slide 60
What are the principles of treatment of haemostatic disorders causing bleeding?
Slide 61
How does desmopressin (DDAVP) work as a haemostatic treatment
Slide 63
How does tranexamic acid work as a haemostatic treatment?
Slide 64
