Haemopoiesis Flashcards
Haemopoiesis
Process of creating new blood cells in the body
Common myeloid progenitors
Erythrocytes
Mast cells
Myeoblasts
Megakaryocyte
Common lymphoid progenitors
Natural killer cells
Lymphocytes
Small lymphocytes
T lymphocytes
B lymphocytes
B lymphocytes
Plasma cells (produce antibodies)
Myeoblast
Basophils ( granules)
Neutrophil
Eosinphil
Monocyte
Monocyte
Macrophages
Megakaryocytes
Thrombocytes - platelets
Erythropoietin
Thrombopoietin
Interleukins
GCSF
Erythropoietin- erythrocytes
Thrombopoietin- platelets (thrombocytes)
Interleukins - common lymphoid progenitor cells
GCSF - WBC s
Where is haemoglobin produced in a foetus and in an adult
foetus:
Liver
Spleen
Yolk sac
Adult :
Bone marrow
Neutrophils
Multilobulated - multi nucleated
Phagocytic
Purple granules contain degradation enzymes
E.g elastase
Eosinophils
Bilobulated nucleus - horse shoe
Secrete histamine - inflammatory response
Orange granules
Stain pink
Monocytes - macrophages when outside tissue
Bilobulated - horse shoe
Purple granules - contain enzymes
Antigen presenting cells
Basophils
Bilobulated nucleus - horse shoe
Secrete histamine - inflammatory response
Stain Purple
Helper T cells
Stimulate further inflammation
Stimulate B cells
Stimulate killer T cells
Suppressor T cells
Turn off cell mediated response
B Cells
Differentiate into plasma cells that are filled with ribosomes
Make and secrete antibodies
Antibodies bind to pathogen - decreases pathogenic activity
Natural killer cells
Stimulate cells to perform apoptosis
Adaptive immunity
Macrophages engulfs pathogen
Present antigen on surface
Detected by specific helper T cells
T cells rapidly divide
Stimulate - phagocytic activity by macrophages
-inflammatory response
- Killer T cells (cell mediated) - kill pathogen or stimulate apoptosis (NK)
- B cells (humoral) - plasma cells produce antibodies which stimulate macrophages to engulf and destroy. Memory B cells produced
Polycynthemia
High RBC count
Leukaemia
High WBC count
Thrombocynemia
Platelet levels high
Anaemia
Low Hb
Leukopenia
Low WBC
Thrombocytopenia
Low platelet count
Pancytopenia
Low counts of blood constituents
