Haemopoiesis Flashcards

1
Q

Haemopoiesis

A

Process of creating new blood cells in the body

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2
Q

Common myeloid progenitors

A

Erythrocytes
Mast cells
Myeoblasts
Megakaryocyte

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3
Q

Common lymphoid progenitors

A

Natural killer cells

Lymphocytes

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4
Q

Small lymphocytes

A

T lymphocytes

B lymphocytes

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5
Q

B lymphocytes

A

Plasma cells (produce antibodies)

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6
Q

Myeoblast

A

Basophils ( granules)
Neutrophil
Eosinphil
Monocyte

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7
Q

Monocyte

A

Macrophages

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8
Q

Megakaryocytes

A

Thrombocytes - platelets

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9
Q

Erythropoietin
Thrombopoietin
Interleukins
GCSF

A

Erythropoietin- erythrocytes
Thrombopoietin- platelets (thrombocytes)
Interleukins - common lymphoid progenitor cells
GCSF - WBC s

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10
Q

Where is haemoglobin produced in a foetus and in an adult

A

foetus:
Liver
Spleen
Yolk sac

Adult :

Bone marrow

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11
Q

Neutrophils

A

Multilobulated - multi nucleated
Phagocytic
Purple granules contain degradation enzymes
E.g elastase

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12
Q

Eosinophils

A

Bilobulated nucleus - horse shoe
Secrete histamine - inflammatory response
Orange granules
Stain pink

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13
Q

Monocytes - macrophages when outside tissue

A

Bilobulated - horse shoe
Purple granules - contain enzymes
Antigen presenting cells

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14
Q

Basophils

A

Bilobulated nucleus - horse shoe
Secrete histamine - inflammatory response
Stain Purple

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15
Q

Helper T cells

A

Stimulate further inflammation
Stimulate B cells
Stimulate killer T cells

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16
Q

Suppressor T cells

A

Turn off cell mediated response

17
Q

B Cells

A

Differentiate into plasma cells that are filled with ribosomes
Make and secrete antibodies
Antibodies bind to pathogen - decreases pathogenic activity

18
Q

Natural killer cells

A

Stimulate cells to perform apoptosis

19
Q

Adaptive immunity

A

Macrophages engulfs pathogen
Present antigen on surface
Detected by specific helper T cells
T cells rapidly divide
Stimulate - phagocytic activity by macrophages
-inflammatory response
- Killer T cells (cell mediated) - kill pathogen or stimulate apoptosis (NK)
- B cells (humoral) - plasma cells produce antibodies which stimulate macrophages to engulf and destroy. Memory B cells produced

20
Q

Polycynthemia

A

High RBC count

21
Q

Leukaemia

A

High WBC count

22
Q

Thrombocynemia

A

Platelet levels high

23
Q

Anaemia

A

Low Hb

24
Q

Leukopenia

A

Low WBC

25
Q

Thrombocytopenia

A

Low platelet count

26
Q

Pancytopenia

A

Low counts of blood constituents