Haemopoiesis

Question 1

Where are the main sites of haemopoiesis

Answer 1

In the bone marrow of:

Pelvis, Sternum, Skull, Ribs and Vertebrae

Question 2

What are the five major lineage pathways that arise from haemopoietic stem cells

Answer 2

Thrombopoiesis

Granulopoiesis

Monocytopoiesis

Lymphopoiesis

Erthyropoiesis

Question 3

What is thrombopoiesis

Answer 3

Formation of platelets involved in blot formation

Platelets are essentially membrane bound fragments of cytoplasm that bud off of megakaryocytes.

Megakaryocyte formation is driven by thrombopoietin

Question 4

What is granulopoiesis and what cells does it produce

Answer 4

Process to produce granulocytes- basophils, neutrophils, eosinophils

Myeloblast cells differentiate into these cell types

Question 5

What is monocytopoiesis

Answer 5

The production of monocytes from myeloblast cells

Monocytes then differentiate into macrophages or dendritic cells when they enter tissues

Question 6

What is lymphopoiesis and explain how the two types of lymphocytes are formed

Answer 6

Production of B and T lymphocytes from common lymphoid progenitor cells

B lymphocyte production begins in the foetal liver and bone marrow with immunoglobulin genes rearranging during development to allow from production of antibodies

T lymphocyte production begins in the foetal liver and then the T lymphocyte progenitors migrate to the thymus early in gestation