Haemoglobinopathy Flashcards
1
Q
Describe the structure of haemoglobin
A
2 alpha and 2 beta globin chains
1 haem group attached to each globin chain
2
Q
What is haemoglobin A made up of?
A
2A2B
3
Q
What is haemoglobin A2 made up of?
A
2A2D
4
Q
What is haemoglobin F made up of?
A
2A2Y
5
Q
Where are haemoglobin genes found?
A
A is on chromosome 16
B is on chromosome 11
6
Q
What are thalassaemias?
A
Hereditary disorders of globin chain synthesis resulting in impaired haemoglobin production.
7
Q
What types of thalassaemia exist?
A
Alpha and Beta
8
Q
What effect does thalassamia have on red blood cells?
A
microcytic hypochromic anaemia
9
Q
What is the result of the unbalanced accumulation of globin chains?
A
Ineffective erythropoiesis and haemolysis
