Haemoglobin

Question 1

what does haemoglobin carry

Answer 1

o2

Question 2

what is the large protein globing composed of

Answer 2

4 polypeptide chains (tetramer)

2 alpha, 2 beta

Question 3

how many hb molecules does each roc contain approximately

Answer 3

200-300 million

Question 4

normal values of haemoglobin in males and females

Answer 4

males 130-180g/L

females 120-160g/L

Question 5

what does each haemoglobin chain include

Answer 5

a haem-iron complex

Question 6

what gives blood the red colour

Answer 6

haem

Question 7

what’s haem made of

Answer 7

organic part made up of 4 pyrrole rings

central iron ion in ferrous state (Fe2+)

Question 8

how many O2 can each haemoglobin molecules transport

Answer 8

4

Question 9

what does oxygen + haemoglobin produce

Answer 9

oxyhaemoglobin

Question 10

what’s partial pressure like in lungs if oxygen is abundant

Answer 10

high

Question 11

where is oxyhemoglobin higher in body

Answer 11

lungs

Question 12

what’s partial pressure like in tissues and why

Answer 12

lower

as less O2 there so its released from haemoglobin

Question 13

what haemoglobin is present in tissues (dark red)

Answer 13

deoxyhaemoglobin

Question 14

what causes a small change in haemoglobin shape

how does this affect O2 binding

Answer 14

oxygen binding to 1 subunit

makes O2 binding slightly easier - increases oxygen affinity with the rest of haem groups