haemoglobin 1: oxygen dissociation curve Flashcards
1
Q
what does the oxygen dissociation curve show?
A
O2 carrying capacity of Hb at different pO2
2
Q
what is the shape of the oxygen dissociation curve?
A
sigmoid shape - binding of one molecule facilitates further binding (cooperativity)
3
Q
what is P50?
A
26.6mmHg / 4kpa - partial pressure of O2 at which Hb is half saturated with O2
4
Q
what causes the curve to shift?
A
left (increased affinity): HbF, increased pH
right: HbS, increased 2,3DPG
