Haematostasis and Thrombosis - Clinical Cases

Question 1

Is the clinical presentation of haemophilia A and B the same?

Answer 1

Clinical presentation of A and B are the same, differentiate between the two by measuring factor VIII or IX levels

Question 2

How does haemophilia often present?

Answer 2

Joint bleeding

Question 3

Describe the inheritance of haemophilia?

Answer 3

Inheritance is X linked

Question 4

Describe the treatment of haemophilia?

Answer 4

• Recombinant factor VIII (if A)

Question 5

What are possible complications of recombinant factor as treatment for haemophilia?

Answer 5

• Infection
  
  • Hep B, Hep C, HIV
• Development of inhibitory antibodies

Question 6

Describe the aetiology of thrombocytopenia?

Answer 6

• AML
• Aplastic anaemia
• ITP

Question 7

What is thrombocytopenia associated with?

Answer 7

• HIV infection
• SLE
• Glandular fever

Question 8

Describe the presentation of thrombocytopenia?

Answer 8

• Easy bruising
• Petechiae

Question 9

What is the difference between petechiae and spider naevi?

Answer 9

Petechiae are skin lesions that do not blanch, spider naevi do

Question 10

Describe the presentation of poor surgical technique causing issues post-surgery?

Answer 10

• Bleeding from abdominal wound after surgery, but not from drain or line

Question 11

What are indications for LMWH for thromboprophylaxis before surgery?

Answer 11

• Surgery
• Elderly
• Active cancer

Question 12

What is aspirins mechanism of action?

Answer 12

• Inhibits platelet function by inhibiting COX-1