Haematopoiesis

Question 1

Describe the developmental pathway of RBCs, Platelets. Monocytes, Neutrophils/basophil/eosinophil and lymphocytes

Answer 1

HSCs differentiate into either common myeloid progenitor (CMP) or common lymphoid progenitor (CLP)

CMP differentiates into megakaryocyte erythroid progenitor (MEP), which either becomes a RBC or megakaryocyte (platelets).

CMP also differentiates into granulocyte monocyte progenitor (GMP), which either becomes monocyte (macrophages) or granulocytes (neutrophil, basophil, eosinophil)

CLPs become our lymphocytes - NK cells and B and T cells.

Question 2

Describe the steps of maturation for a RBC

Answer 2

Megakaryocyte erythroid progenitor -> Proerythroblast -> Erythroblast -> Nuclear extrusion -> Reticulocyte -> RBC

Question 3

What is the criticla step in maturation of a RBC?

Answer 3

Nuclear extrusion, going from erythroblast to reticulocyte. This stays in marrow for a couple of days and then mature into an erythrocyte in peripheral blood.

Question 4

Describe the maturation stesp of a myeloblast into basophil/neutrophil/eosinophil.

Answer 4

Myeloblast -> B/N/E promyelocyte -> B/N/E myelocyte -> B/N/E metamyelocyte -> B/N/E band cell -> Basophil/Neutrophil/Eosinophil