Haematopoeisis Flashcards

1
Q

What do all blood cells develop from?

A

Multipotent Haematopoeietic Stem Cell

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2
Q

What 2 main cell lines develop from haematopoietic stem cells?

A

Myeloidblasts and Lymphoblasts

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3
Q

What cytokines stimulates production of megakaryocytes?

A

Thrombopoietin

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4
Q

What cytokines stimulates production of erythrocytes?

A

Erythropoietin

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5
Q

What cytokine stimulates production of lymphocytes?

A

Interleukin

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6
Q

What cytokine stimulates granulocyte production?

A

G-CSF (Granulocyte colony stimulating factor)

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7
Q

What do megakaryocytes develop into?

A

Thrombocytes (make platelets)

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8
Q

Where does. Haemopoiesis occur in embryos?

A

Starts in the yolk sac > then the liver> then the spleen

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9
Q

What is the average life cycle of an erythrocyte?

A

120 days

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10
Q

What is the order of activation of granulocytes in the innate immune system?

A
Neutrophils
Leukocytes
Monocytes
Eosinophils
Basophils 

THINK: Never Let Monkeys Eat Bananas

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11
Q

What do neutrophils do?

A

Migrate from circulation to infection sites to destroy cells by phagocytosis

Have a multilobed nucleus and small granules in cytoplasm

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12
Q

What do eosinophils do?

A

Phagocytose cells and release cytotoxic enzymes to destroy large particles

Bi lobed cell, numbers increase with allergic reactions

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13
Q

What do Basophils do?

A

Mediate inflammatory reactions by releasing heparin (prevents coagulation) and histamine (mast cell degranulation)

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14
Q

What do monocytes do?

A

Move out of circulation 20-40hrs after immune response initiated
Become macrophages - able to phagocytose cells and interact with T cells

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15
Q

What is pancytopenia?

A

Deficiency in ALL blood cell types

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