Haematopoeisis Flashcards
What do all blood cells develop from?
Multipotent Haematopoeietic Stem Cell
What 2 main cell lines develop from haematopoietic stem cells?
Myeloidblasts and Lymphoblasts
What cytokines stimulates production of megakaryocytes?
Thrombopoietin
What cytokines stimulates production of erythrocytes?
Erythropoietin
What cytokine stimulates production of lymphocytes?
Interleukin
What cytokine stimulates granulocyte production?
G-CSF (Granulocyte colony stimulating factor)
What do megakaryocytes develop into?
Thrombocytes (make platelets)
Where does. Haemopoiesis occur in embryos?
Starts in the yolk sac > then the liver> then the spleen
What is the average life cycle of an erythrocyte?
120 days
What is the order of activation of granulocytes in the innate immune system?
Neutrophils Leukocytes Monocytes Eosinophils Basophils
THINK: Never Let Monkeys Eat Bananas
What do neutrophils do?
Migrate from circulation to infection sites to destroy cells by phagocytosis
Have a multilobed nucleus and small granules in cytoplasm
What do eosinophils do?
Phagocytose cells and release cytotoxic enzymes to destroy large particles
Bi lobed cell, numbers increase with allergic reactions
What do Basophils do?
Mediate inflammatory reactions by releasing heparin (prevents coagulation) and histamine (mast cell degranulation)
What do monocytes do?
Move out of circulation 20-40hrs after immune response initiated
Become macrophages - able to phagocytose cells and interact with T cells
What is pancytopenia?
Deficiency in ALL blood cell types