haematology - haemolytic anaemias Flashcards
1
Q
define haemolytic anaemia
A
anaemia due to breakdown of RBC before normal life span of 120 days
2
Q
types of haemolytic in haemolytic anaemia
A
intravascular
extravascular
3
Q
causes of haemolytic anaemias
A
inherited
- membrane defect
- enzyme defect
- haemoglobinopathies
acquired
- immune
- autoimmune
4
Q
features of all haemolytic anaemias
A
↑ unconjugated bilirubin ↑ urobilinogen ↑ LDH reticulocytosis pigmented gallstones
5
Q
features of intravascular haemolytic anaemias
A
↑ free plasma Hb
↓ haptoglobin
haemoglobinuria
methaemalbuminaemia
6
Q
hereditary spherocytosis/elliptocytosis causes haemolytic anaemia because of
A
membrane defect
7
Q
G6PD deficiency causes haemolytic anaemia because of
A
enzyme defect
8
Q
pyruvate kinase deficiency causes haemolytic anaemia because of
A
enzyme defect
9
Q
SCD/thalassaemia causes haemolytic anaemias because
A
they are haemoglobinopathies
