Haematology and Oncology Flashcards
1
Q
4 yo M, pallor, lethargy, fever, leg pain, generalised adenopathy, hepatomegally, bruising? DDx
A
Acute Leukaemia
2
Q
What percentage of paediatric cancer is ALL?
A
25-30%
3
Q
What percentage of childhood leukaemia is ALL?
A
75-80%
4
Q
What is the peak age incidence of ALL?
A
Age 2-5 - theory of “second hit” with viral exposure
5
Q
What are the common genetic translocations of AML and ALL?
A
AML - t(4:11)
ALL - t(12:21)
6
Q
What is the concordance rate of ALL in identical twins?
A
Dichorionic - 25%
Monochorionic - 100% - idea of shared circulation of pre-leukaemic cells - first “hit” intrauterine
7
Q
What is the Philadelphia chromosome?
A
t(9:22) - 90% of adult CML and 25% of paediatric ALL
