Haematology and Oncology Flashcards

1
Q

4 yo M, pallor, lethargy, fever, leg pain, generalised adenopathy, hepatomegally, bruising? DDx

A

Acute Leukaemia

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2
Q

What percentage of paediatric cancer is ALL?

A

25-30%

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3
Q

What percentage of childhood leukaemia is ALL?

A

75-80%

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4
Q

What is the peak age incidence of ALL?

A

Age 2-5 - theory of “second hit” with viral exposure

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5
Q

What are the common genetic translocations of AML and ALL?

A

AML - t(4:11)

ALL - t(12:21)

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6
Q

What is the concordance rate of ALL in identical twins?

A

Dichorionic - 25%

Monochorionic - 100% - idea of shared circulation of pre-leukaemic cells - first “hit” intrauterine

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7
Q

What is the Philadelphia chromosome?

A

t(9:22) - 90% of adult CML and 25% of paediatric ALL

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