Haematology Flashcards
Which among the following characteristics of oxyglobin is false:
- Development of haemoglobinemia
- Risk of anaphylactic reactions following the first inj
- Short duration of effect
- Increase systemic arterial pressure
Risk of anaphylactic reactions (this happens with human/bovine albumin)
Developed of haemoglobinemia (but also icterus and haemoglobinuria)
Duration: 18-43 hours
Increase both systemic and pulmonary arterial pressure
What are the Vit K dependent factors?
- II, V, VI, VIII
- V, VII, IX, X
- II, VII, IX, X
- V, VII, IX, X
II, VII, IX, X
Von Willebrand factors interacts with, and acts as a carrier for, which plasma coagulation factor?
- V
- VII
- VIII
- IX
- VIII
Which inherited coagulation factor deficiency is associated with prolongation of both the prothrombin time (PT) and the activated partila thromboplastin time (APTT)?
- Factor II deficiency (hypoprothrombinaemia)
- Factor VII deficiency (Haemophilia A)
- Factor IC deficiency (Haemophilia B)
- Factor XII deficiency (hangman trait)
- Factor II deficiency (hypoprothrombinaemia)
Haemophilia (A and B): prolongation APTT with normal PT
Factor XII deficiency (hangman trait): clinically irrelevant incidental finding as it is not associated with clinical bleeding
Which of the following drug is not recommended in the treatment of IMHA?
- Azathioprine
- Chlorambucil
- Cyclosporin
- Leflunomide
- Chlorambucil
Which breed is mostly affected by the Chediak-Higashi disease?
- Doberman
- Maine Coon
- Persian
- Poodle
2.Persian.
“Chediak-Higashi syndrome (CHS) is a rare, inherited, complex, immune disorder that is characterized by reduced pigment in the skin and eyes (oculocutaneous albinism), immune deficiency with an increased susceptibility to infections, and a tendency to bruise and bleed easily
Which of the following is NOT associated with monoclonal gammopathy?
- Pyoderma
- Plasmacitic enteritis
- Multiple myeloma
- Gingivitis
- Gingivitis
N 1. 2. and 3. have been reported to be associated with monoclonal gammopathy.
Others: lymphoma (B-cell; T-cell, am I right?). Leishmania. Eirlichia.
Which of the following are negative acute-phase proteins?
- Albumin
- C-reactive peptide
- Transferrin
- Serum amyloid A
- Albumin and 3. Tranferrin are the major negative acute-phase proteins.
Positive APP are produced by the liver after stimuli including IL-1 IL-2 IL-6 and TNF alfa.
Cause of elevated AST in face of normal ALT and CK.
- Muscle injury
- Impossible
- Haemolysis
- CKD
- Haemolysis
Which of the following is the disease that most likely will not give clinical signs?
- von Willebrand disease type 3
- vWF disease type 2
- Hageman’s trait (XII deficiency)
- Glanzman disease (GpIIb/IIIa fibrinogen receptor anomaly)
- Hageman’s trait (XII def.) common in cats. asymptomatic.
vVF disease type 3 very symptomatic. type 2 symptomatic.
Glanzaman (Pyrenees dogs) is symptomatic.
In which of the following disorders we have increased PT with a normal aPTT?
- VII deficiency
- V deficiency
- von Willebrand disease
- Scott disease
- VII deficiency.
The normal APTT supports that intrinsic and common factor pathway factors are not deficient. The only one remaining is factor VII.
vVF disease have both PT and aPTT increased.
Scott disease is a platelet defect (german S. dog) in which platelets won’t create a negative phosptatidilserin negative charge that usually activated factor XII. PT and aPTT will be normal. Genetic testing needed for diagnosis.
Where/how does clopidogrel work?
- inhibits factor X
- Inhibits factors II, IX and X.
- blocks ADP platelet receptor (P2Y12)
- blocks Thromboxan A2 platelet production
- Blocks irreversibly ADP receptor (P2Y12)
- inhibits factor X : this is APIXABAN/ riveroxaban
- Inhibits factors II, IX and X. This is the action of antithrombin III that is activated/increased by HEPARIN.
- blocks Thromboxan A2 platelet production. This is ASPIRIN
Which of the following is NOT true
- Cobalamin is abundant in animal proteins
- Cobalamin ligates R-protein
- Cobalamin requires a receptor to be absorbed from the intestine
- Cobalamin is absorbed from the duodenum.
- Cobalamin is absorbed from the duodenum is false. It is absorbed from the ileum.
- Yes it is abundant in animal prot (vegetarian low B12).
- Yes it ligates R factor to survive the gastric acid
- Yes requires a receptor that binds the complex B12-I.F. in the ileum to be absorbed (and requires transcobalamin to be transported in the blood stream).
An increase of the blood glucose will cause:
- An increase of Na due to renal reabsorption
- An increase of Cl due to co-trasport mechanism
- A reduction of Na due to osmotic effect
- An increase of Na due to osmotic effect
- A reduction of Na due to osmotic effect
Glucose bring more water intravascularly which “dilute” the Na
Which of the following statements regarding rodenticide toxicity in dogs is CORRECT?
- Activated partial thromboplastin time (APTT) becomes prolonged before prothrombin time (PT).
- Anticoagulant rodenticides inhibit the recycling of Vitamin K from Vitamin K epoxide.
- Anticoagulant rodenticides result in reduced activity of clotting factors II, VII, IX and XI.
- Vitamin K1 should be administered intravenously.
- Anticoagulant rodenticides inhibit the recycling of Vitamin K from Vitamin K epoxide.
Iv could cause anaphylaxis, increased of PT then aPTT and factors are II, VII, IX and X
