Farmacology

Question 1

What is the mechanism of action of ondansetron?

1. D2 antagonist
2. Serotonin (5-ht3) receptor antagonist
3. H1 antagonist
4. NK1 antagonist

Answer 1

2. Serotonin (5-ht3) receptor antagonist

D2 antagonist = metoclopramide
H1 antagonist = cetirizine
NK1 antagonist = maropitant

Question 2

How does sildanephil work?

1. Serotonine 5-ht3 receptors antagonist
2. Phospodiesterase-3 inhibitors
3. Ca channel blocker in pulmonary arteries and angiotensin II antagonist systemically
4. Phospodiesterase-5 inhibitors

Answer 2

Phospodiesterase-5 inhibitors

Question 3

Where Maropitant work?

1. Centrally
2. Peripherally
3. Both
4. None

Answer 3

3. Both

Question 4

Administration of a drug that block beta-adrenoceptors would be expected to:

1. Decrease the recreation of ACTH from the pituitary
2. Decrease the secretion of insulin form the pancreas
3. Increase the force of the cardiac contraction
4. Increase the heart rate

Answer 4

2. Decrease the secretion of insulin form the pancreas

Question 5

What is the mode of action of clopidogrel?

1. Antagonist of the ADPP2Y12 receptor on platelets
2. Antagonist of the gpib-IX-V receptors on platelets
3. Prevention of thromboxane A2 formation
4. Factor Xa inhibition

Answer 5

1. Antagonist of the ADPP2Y12 receptor on platelets

gpib-IX-V receptors on platelets: it binds with VW factor
Prevention of thromboxane A2 formation: Aspirine
Factor Xa inhibition: apixaban, heparin

Question 6

What is the mechanism of action of metoclopramide?

1. D2 antagonist
2. NK1 antagonist
3. 5-HT3 antagonist
4. H1 antagonist

Answer 6

1. D2 antagonist

Question 7

What is the emetic mechanism of action of apomorphine?

1. alpha-2 agonist
2. 5-HT1 agonist
3. D2 agonist
4. H1 agonist

Answer 7

3. D2 agonist

D1 and D2 agonist- weak effect in cats due to lack of D2.