Haematology

Question 1

What is the rate of HITS with heparin?

Answer 1

2-4%

Question 2

What is the rate of HITS with enoxaparin?

Answer 2

0.6%

Question 3

What is the diagnostic criteria for HITS?

Answer 3

Diagnosed through combination of clinical and laboratory factors

4T score
4-5 intermediate probability
6-8 high probability

Question 4

What is the 4T score for HITS?

Answer 4

Thrombocytopenia (fall and and nadir)
Timing (5-10 days after exposure most likely)
Thrombosis (confirmed, suspected, none)
Thrombocytopenia - other causes (none/possible/definite)

Question 5

Treatment of HITS?

Answer 5

Cease heparin anticoagulant
Start non heparin anticoagulant
Continue for 4 weeks if no thrombosis, or three months if has had thrombosis

Question 6

What is the best test to assess for residual dabigatran activity?

Answer 6

Thrombin time

Question 7

What is the best test to assess for residual rivaroxaban/apixaban activity?

Answer 7

Anti Xa level

PT/INR

Question 8

What is the risk of thrombosis with APLS with SLE?

Answer 8

4% per year