Haematology Flashcards
What is the mechanism of action of Rivaroxaban?
Direct factor Xa inhibitor
What is likely to precede idiopathic thrombocytopenic purpura?
Self-limiting viral infection eg. glandular fever
What is the mechanism of action of Dabigatran?
Direct thrombin inhibitor
What is the single most important factor in determining whether cryoprecipitate should be given?
A low fibrinogen level
What haematological condition can cause thrombocytosis?
Chronic myeloid leukaemia
What is the recommended treatment for post-thrombotic syndrome?
Graduated compression stockings
What are the causes of secondary polycythaemia?
- COPD
- Altitude
- Obstructive Sleep Apnoea
- Excessive erythropoietin - cerebellar haemangioma, hypernephroma, hepatoma, uterine fibroids
What is the likely diagnosis in a patient presenting with:
- dyspnoea
- chest pain
- cough
- hypoxia
- new pulmonary infiltrates seen on chest X-ray
Acute chest syndrome (complication of sickle cell)
What would an FBC from a patient with alcoholic liver disease who had consumed alcohol immediately prior to the test show?
Macrocytic anaemia and thrombocytopenia
Why do patients with Factor V Leiden have an increased risk of thromboembolic events?
Activated factor V is inactivated 10 times more slowly by activated protein C than normal
What is the length of warfarin treatment following VTE?
Provoked (eg. surgery):
- 3 months
Unprovoked:
- 6 months
Failure to thrive Jaundice, gallstones Splenomegaly Aplastic crisis precipitated by parvovirus infection Elevated MCHC
…are all presentations of which condition?
Hereditary spherocytosis
What is the most common leukaemia in adults in the western world?
B cell Chronic Lymphocytic Leukaemia
Which condition is characterised by:
- peripheral blood lymphocytosis
- uncontrolled proliferation of small, mature lymphocytes in bone marrow, lymph nodes and spleen
Chronic Lymphocytic Leukaemia
What is the commonest cause of tumour lysis syndrome?
Burkitt’s lymphoma
