Haematology Flashcards
What is iron deficiency anaemia?
Iron deficiency anaemia develops when body stores of iron drop too low to support normal red blood cell (RBC) production
Need 20mg/day for RBC production, get 20mg back from RBC destruction
Loss of 1-2mg daily so need 1-2mg absorbed daily
Symptoms of iron deficiency anaemia (if extreme)
- Fatigue and diminished capability to perform hard labour
- Leg cramps on climbing stairs
- Craving ice (in some cases, cold celery or other cold vegetables) to suck or chew
- Poor scholastic performance
- Cold intolerance
- Reduced resistance to infection
- Altered behaviour (attention deficit disorder)
- Dysphagia with solid foods (from oesophageal webbing)
- Worsened symptoms of comorbid cardiac or pulmonary disease
Signs of iron deficiency anaemia
- Impaired growth in infants
- Pallor of the mucous membranes (a nonspecific finding)
- Spoon-shaped nails (koilonychia)
- A glossy tongue, with atrophy of the lingual papillae
- Fissures at the corners of the mouth (angular stomatitis)
- Splenomegaly (in severe, persistent, untreated cases)
What investigations need to be done in suspected anaemia
• FBC (microcytic anaemia)
• Serum iron, total iron-binding capacity (TIBC), and serum ferritin
• Evaluation for haemosiderinuria, haemoglobinuria, and pulmonary Haemosiderosis
• Coeliac screen/small bowel disease?
Find source of bleeding?
Treatment of iron deficiency anaemia?
- Oral iron supplementation with ferrous sulphate
- Blood transfusions is necessary
- Diet advice: apricots, chicken, turkey, fish, other meats, dried beans, lentils, and soybeans, eggs, liver, molasses, oatmeal, peanut butter, prune juice, raisins and prunes, spinach, kale and other greens
What is anaemia caused by?
Lack of RBCs in circulation
Either inadequate production or increased breakdown
Causes of anaemia due to inadequate production
- Marrow failure (aplastic anaemia)
- Nutrient deficiency (iron, folate, B12)
- Reduced iron due to bleeding (eg gut) (+low platelets)
- Pure red cell (sickle cell, haemoglobinopathies)
- Leukaemia (infiltration)
- Lack of erythropoietin (kidney issue)
Causes of anaemia due to increased breakdown
- Bleeding (bowel cancer, coeliac)
- Haemolysis (structural or due to antibodies)
- Antibodies (SLE, infectious disease, rhesus disease)
What investigations are needed in anaemia?
- FBC & film (sickle cell?)
- LFTs
- Direct coombs test
- Coeliac screen
- Bone marrow biopsy
- Iron, B12, folate levels
- Coeliac screen
Causes of microcytic anaemia
. Iron deficiency
. Sideroblastic
. Thalassaemia
Causes of normocytic anaemia
Acute blood loss
Haemolytic anaemia
Sickle cell
Causes of macrocytic anaemia
B12 or folate deficiency
What is a haemoglobinopathy?
- Genetic defect in the globin chains, usually autosomal recessive
- Tend to precipitate haemolysis, altered oxygen affinity, unwanted oxidation of iron
Give 3 examples of haemoglobinopathies
Eg sickle cell, HbS, HbC
What is thalassaemia?
Thalassaemias= Reduced or absent production of normal α or β-globin chains, leading to reduced levels of HbA, the main adult Hb. They are very diverse disorders at the genetic and clinical levels
What is ß-thalassaemia major?
Reduced ß chain production
β-thalassaemia major patients are transfusion dependent
Life-threatening anaemia develops in the first year of life as levels of fetal Hb (HbF) decline and adult HbA cannot be produced
Describe sickle cell sequelae
• Vaso-occlusive episodes causing recurrent acute painful sickle cell crises and syndromes such as stroke or acute chest syndrome
• Chronic haemolytic anaemia (Hb commonly 60 to 80 g/L in HbS/S)
• Splenic atrophy and hyposplenism (due to splenic infarction) with increased susceptibility to sudden overwhelming infection by encapsulated bacteria such as Streptococcus pneumoniae and Streptococcus meningitides
• Chronic organ damage, such as chronic kidney disease and joint damage from avascular necrosis, caused by recurrent sickling episodes.
No malaria in carriers
Management of sickle cell disease
- Black African descent
* Have both top-up transfusions and exchange transfusions (eg after stroke)