Development Flashcards
When should you be concerned about a child’s growth?
1) Fall over 2 or more percentiles
2) Are persistently below 3rd/5th percentile
3) Are less than 80th percentile of median weight for height
What is child’s growth dependent on? Adolescent growth?
Children’s growth is dependent on nutrition and growth hormone
In adolescence sex hormones drive the majority of growth and cause the growth plates to fuse.
Causes of short stature
- Chronic disease
- Familial short stature (bone age appropriate for chronologic age, normal growth velocity, and predicted adult height appropriate to the familial pattern)
- Constitutional delay of growth and development (delayed bone age, normal growth velocity, and predicted adult height appropriate to the familial pattern)
- Growth failure (pathologic state of abnormally low growth rate over time, usually endocrine, usually not skinny)
Malnutrition is a huge cause
Consider anorexia/bulemia
Metabolic disease?
Formula/food intolerance/allergy
GI causes of growth failure
Malabsorption
IBD
Cardiac causes of growth failure
Hypoxaemia
Congestive heart failure
Pulmonary causes of growth failure
Severe asthma (chronic steroid use)
CF
Sleep apnoea
Renal/endocrine causes of growth failure
Chronic renal disease Hypothyroidism Growth hormone or IGF deficiency GHRH deficiency Panhypopituitarism Poorly controlled T1DM Chronic hyponatraemia Cushing's Addison's
Genetic causes of growth failure
Down’s
Turner’s
Hypochondroplasia
What is normal puberty in girls?
Begins aged 11 with breast budding Pubic hair Axillary hair Height spurt Ends aged 13 with menarche
What is normal puberty in boys?
Begins aged 12 with testicular enlargement Penis enlargement Pubic hair Height spurt Ends aged 14/15 with facial hair
What counts as precocious puberty?
Pubertal changes before 8 in girls and 9 in boys
Central: gonadotropin-dependent, is the early maturation of the entire hypothalamic-pituitary-gonadal (HPG) axis, with the full spectrum of physical and hormonal changes of puberty.
Precocious pseudopuberty: much less common-> increased production of sex steroids is gonadotropin-independent
What happens to growth in precocious puberty?
The early growth spurt initially can cause tall stature, but rapid bone maturation can cause linear growth to cease too early and can result in short adult stature.
Causes of precocious puberty?
• Usually no CNS change is seen but sometimes->
• Tumours (eg, astrocytomas, gliomas, germ cell tumours secreting HCG)
• Hypothalamic hamartomas
• Acquired CNS injury caused by inflammation, surgery, trauma, radiation therapy, or abscess
• Congenital anomalies (eg, hydrocephalus, arachnoid cysts, suprasellar cysts)
Congenital adrenal hyperplasia
Ovarian oestrogen secreting tumours
Treatment of precocious puberty
Excision/radiotherapy of tumour
GnRH analogue to provide negative feedback on system
GnRH agonist at constant rate (axis only responds to pulsatile secretions)
Progestin (to stop menses)
What counts as delayed puberty?
No change seen at 13 in girls or 14 in boys