Haematological disease

Question 1

Myeloma/multiple myloma clinical features?

Answer 1

Calcaemia (hyper)
Renal failure
Anemia
Bony pain

Question 2

Myeloma/multiple myeloma investigation findings

Answer 2

Monoclonal proteins (usually IgG or IgA) in the seum and urine (as well as bence jones proteins.) MRI is the most useful test.

Question 3

Myelofibrosis clinical features?

Answer 3

Myeloproliferative disorder caused by hyperplasia of megakaryocytes (the resultant release of platelet derived growth factor stimulates fibroblasts) Elederly person w/ symptoms of anaemia, massive splenomegaly and weight loss night sweats etc.

Question 4

Myelofibrosis investigation findings?

Answer 4

anaemia, high WBC and Plt early in the disease, unobtainable bone marrow biopsy (therefore trephine biopsy needed) tear drop poikilocytes on blood film. High urate and LDH