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Finals > Cancer markers and autoantibodies > Flashcards

Cancer markers and autoantibodies Flashcards

1
Q

CA 125

A

Ovarian cancer

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2
Q

CA 19-9

A

Pancreatic cancer

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3
Q

CA 15-3

A

Breast cancer

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4
Q

PSA

A

Prostatic carcinoma

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5
Q

Alpha-feto protein (AFP)

A

Hepatocellular carcinoma, teratoma

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6
Q

S-100

A

Melanoma and schwannomas

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7
Q

Bombesin

A

Small cell lung carcinoma, gastric cancer, neuroblastoma

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8
Q

Ovarian cancer

A

CA 125

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9
Q

Pancreatic cancer

A

CA 19-9

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10
Q

Breast cancer

A

CA 15-3

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11
Q

Prostatic carcinoma

A

PSA

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12
Q

Hepatocellular carcinoma, teratoma

A

Alpha-feto protein (AFP)

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13
Q

Melanoma and schwannomas

A

S-100

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14
Q

Small cell lung carcinoma, gastric cancer, neuroblastoma

A

Bombesin

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15
Q

Carcinoembryonic antigen (CEA)

A

Colorectal cancer

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16
Q

Colorectal cancer

A

Carcinoembryonic antigen (CEA)

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17
Q

ACL

A

Antiphospholipid syndrome

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18
Q

Ferritin

A

Adult onset still’s disease

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19
Q

pANCA

A

Churg-straus angitis, microscopic polyangitis

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20
Q

cANCA

A

Wegener’s granulomatosis

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21
Q

Topoimerase/Scl-70

A

Diffuse sceleroderma (especially lung disease)

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22
Q

Centromere

A

Limited cutaneous scleroderma

23
Q

RNP (ribonuclear protein)

A

Mixed connective tissue disease

24
Q

Antiphospholipid syndrome

A

ACL

25
Q

Adult onset still’s disease

A

Ferritin

26
Q

Churg-straus angitis, microscopic polyangitis

A

pANCA

27
Q

Wegener’s granulomatosis

A

cANCA

28
Q

Diffuse sceleroderma (especially lung disease)

A

Topoimerase/Scl-70

29
Q

Limited cutaneous scleroderma

A

Centromere

30
Q

Mixed connective tissue disease

A

RNP (ribonuclear protein)

31
Q

Smith (Sm)

A

SLE (low sensitivity highly specific)

32
Q

La

A

SLE, Sjogrens

33
Q

Ro

A

SLE, Sjogrens (causes neonatal heart block)

34
Q

Ds DNA

A

80% SLE

35
Q

Antinuclear antibody

A

99.9% SLE

36
Q

Rheumatoid factor/ACPA

A

RA (RF present in Sjogrens)

37
Q

SLE (low sensitivity highly specific)

A

Smith (Sm)

38
Q

SLE, Sjogrens

A

La

39
Q

SLE, Sjogrens (causes neonatal heart block)

A

Ro

40
Q

80% SLE

A

Ds DNA

41
Q

99.9% SLE

A

Antinuclear antibody

42
Q

RA (RF present in Sjogrens)

A

Rheumatoid factor/ACPA

43
Q

anti-mitochondrial antibodies (AMA) M2 subtype smooth muscle antibodies (in 30%) and raised serum IgM

A

Primary biliary cholangitis (previously primary biliary sclerosis)

44
Q

Previous history of UC, ANCA

A

Primary sclerosing cholangitis

45
Q

Lactate dehydrogenase (LDH)

A

Testicular cancer

46
Q

Primary sclerosing cholangitis

A

ANA and ANCA

47
Q

Anti-GBM

A

Goodpastures

48
Q

Polymyositis and Dermatomyositis

A

Jo 1, Mi 2 and ANA

49
Q

Primary biliary cholangitis (previously primary biliary sclerosis)

A

anti-mitochondrial antibodies (AMA) M2 subtype smooth muscle antibodies (in 30%) and raised serum IgM

50
Q

Primary sclerosing cholangitis

A

Previous history of UC, ANCA

51
Q

Testicular cancer

A

Lactate dehydrogenase (LDH)

52
Q

ANA and ANCA

A

Primary sclerosing cholangitis

53
Q

Goodpastures

A

Anti-GBM

54
Q

Jo 1, Mi 2 and ANA

A

Polymyositis and Dermatomyositis

Finals (8 decks)

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