Haem

Question 1

Multiple myeloma features

Answer 1

High calcium, bone pain, renal impairment, anaemia

Question 2

What does anaemia with reduced reticulocytes indicate

Answer 2

Something affecting bone marrow

eg parvovirus b19, aplastic crisis (sickle cell anemia), blood transfusion

Question 3

INR range for DVT

Answer 3

2 to 3

Question 4

AML vs myeloma

Answer 4

See immature blasts in AML

Question 5

ALL vs AML

Answer 5

ALL has organ infiltration, seen in kids

AML has tissue infiltration, increases with age

Question 6

What is seen in haemochromatosis

Answer 6

Hepcidin mutation and deficiency

High serum iron, high ferritin, low transferrin, high transferrin saturation, low TIBC

Question 7

What is seen in IDA

Answer 7

Opposite of haemochromatosis

Question 8

Hodgkins vs NHL

Answer 8

HL; more systemic symptoms, pain after alcohol, reed Sternberg cells
NML; more organ involvement

Question 9

ALP in multiple myeloma

Answer 9

Normal

Question 10

Types of vWD

Answer 10

1; less normal vWF (AD)
2; defective vWF (AD)
3; complete lack of vWF and highly reduced factor 8 (AR)

Question 11

Bleeds seen in vWD

Answer 11

more superficial than haemophilia. type 3 is more severe and see bleeding into joints

Question 12

What is seen in myelofibrosis?

Answer 12

massive splenomegaly. dry tap. dacrocytes. polycythemia ruba vera

Question 13

Aplastic anemia

Answer 13

Bone marrow failure. Pancytopenia

Question 14

Direct antibody test (Coombs)

Answer 14

Autoimmune haemolytic anaemia