Haem

Question 1

Describe the broad subclasses/groups of haematologic malignancy:

Answer 1

Beginning with Bx:
Tissue adequate or inadequate. If adequate:
Reactive vs non reactive:
Non-reactive:
Hod vs NHL
1) NHL:
Immature vs Mature:
- Immature B or T
- Mature B or T
There are 34 types of mature B
2) Hod:
Classic vs Nodular lymphocyte predominant:
Classic = nodular sclerosis, mixed, lymphocyte-rich, lymphocyte-depleted
Nodular = Nodular lymphocyte predominant (not the same as nodular sclerosis).

Question 2

Most types of non-Hodgkin lymphoma begin in:

Answer 2

Most types of non-Hodgkin lymphoma begin in B lymphocytes.

Question 3

Risk factors for Non-Hodgkin lymphoma include

Answer 3

Age, 
male, 
White; 
inherited immune disorder, 
an autoimmune disease, 
HIV/AIDS, 
human T-lymphotrophic virus type I or Epstein-Barr virus infection, 
Helicobacter pylori infection; 
Immunosuppressant drugs after an organ transplant.

Question 4

1) Mature B cell neoplasms comprise over X% of lymphoid neoplasms worldwide
2) The most common types are X and Y which make up 50% of the non-Hodgkin’s lymphomas.

Answer 4

Mature B cell neoplasms comprise over 90% of lymphoid neoplasms worldwide and there are 4% of nw cancers each year. They are more common in developing countries.
The most common types are follicular lymphoma (FL) and diffuse large B-cell lymphoma which make up 50% of the non-Hodgkin’s lymphomas.
The specific B-cell neoplasms frequency vary in different parts of the world. FL is more common in the US and Western Europe. Burkitt’s lymphoma in endemic in Africa.