HA Exam 1 Flashcards
What changes to preoperative care will we do if we delay the surgery
- optimize comorbid diseases
- refer to other specialist
- refer for specialized testing
- initiate interventions intended to decrease perioperative risk
- ID previous unrecognized comorbid conditions
How do we prepare for surgery
- preoperative instructions for surgical patient; bath/ brush teeth. Medications / supplements. OTC/herbal are anticoagulants.
- discuss perioperative care/ expectations
- arrange appropriate level of postoperative care/ plan ahead- dialysis? ICU?
What are the goals for postoperative follow up
- specialist follow up facilitated by preanesthsia evaluation
- Follow - up by anesthesiologist led service
follow up on conditions id by preoperative assessment
Medical history components
Underlying condition requiring surgery
Known medical problems/past medical issues
Previous surgeries/anesthetic history
Anesthetic-related complications-ache deficiency (genetics), mh, difficult airway, PON/V, sleep apnea
Review of systems- heart, lungs, brain,
Medications
Allergies and drug reactions- anesthetic history, family history.
Tobacco/ETOH/Illicit drug use
Functional capacity – how active?
Anesthetic physical exam
heart, lungs, airway, brain
BMI < 18.5
underweight
BMI 18.5-24.9
normal
BMI 25-29.9
overweight
BMI 30 and above
obese
Metric BMI formula
BMI = wt (KG) / Height (m) (squared)
Imperial BMI formula
BMI = 703 x wt (lbs) / height (in) (squared)
Vital signs
BP, HR, RR, O2 saturation, temperature
Height and weight
BMI
Ideal body weight
consider when they were taken
Focused physical exam
Baseline neuro exam
Based upon surgery or procedure
Establish baseline. Pupils**. Seizures/CVA/TIA
CV- CAD/MI/HTN/CHF- maximize
Pulmonary- Asthma/COPD
Airway- previous trach?
Endocrine- BG-Adrenal disorders/DM/thyroid-pheochromocytoma – mass on kidney/ something going on abd.
Hepatobiliary disorders- metabolism?
Renal
Musculoskeletal disorders
Immunocompromised- special handling/ accessing devices.
Obesity- alone increases morbidity and mortality
consider positioning
Emergent physical examination
A = Allergies
M = Medications
P = Past medical history
L = Last meal eaten
E – Events leading up to need for surgery/procedure
Special attention to the evaluation of the
Vital signs (CNS, heart, lung)- pre op spo2
Airway
If regional anesthesia is proposed
Assessment of the site of block - look at back – abcess on back??
Airway Examination
- Mallampati classification
- Inter-incisors gap- between top and bottom teeth
- Thyromental distance- thyroid and ….distance- want 3 fingers
- Forward movement of mandible- recessed/pronounced jaws or lack of mobility
- Range of cervical spine motion: flexion and extension
- Document loose or chipped teeth, tracheal deviation- meth mouth
What accounts for almost half of perioperative mortalities
cardiovasular complications
Some perioperative interventions modify risks for cardiovascular morbidity and mortality
Maxmize pt before taking them to OR
Cardiovascular disorders
Hypertension
Ischemic heart disease
Heart failure- may be baseline
Valvular heart disease
Patients with rhythm disturbances- EP lab - electrolyte abnormalities contribute
Patient with coronary stents- can reocclude w/in 90 days
Patients with pacemakers and ICD devices, pain pumps, dbs, insulin pumps.
Patients with peripheral arterial disease- also bad coronaries/ arterioles.
What has significant effects on respiratory function and lung physiology and mechanics
General anesthesia
Adverse respiratory event can occur during anesthesia and the most significant is hypoxemia
Integrative measures of respiratory function are likely predictors of outcome following anesthesia and surgery
Pulmonary disorder
Upper respiratory tract infection- kids
Asthma and COPD- maximize pts/ avoid GA
Chronic smokers- don’t stop smoking
Restrictive lung diseases- obesity,
Obstructive sleep apnea
Patients scheduled for lung resection-already have lung problems- ventilation problems
Endocrine system
Diabetes Mellitus
Thyroid disorders-medications- T3/T4 (will cause heart problems)- continue Synthroid
Hypothalamic- pituitary- adrenal disorders
Pheochromocytoma
Pit tumors -> ICU – fluid problems
Consider anesthetic effects
Renal system
Surgical stress, anaesthetic agents tend to decrease GFR
Renal impairment- CKD/ AKI
Contrast induced nephropathy
The emphases of the preoperative evaluation of patients with renal insufficiency are on the cardiovascular system, cerebrovascular system, fluid volume, and electrolyte status
BUN / creat – fluid volume status?
Hepatic disorder
Liver diseases have significant impact on drug metabolism and pharmacokinetics
Sedatives/opioids might have exaggerated effects in patients with advanced liver disease
Hepatitis
Alcohol liver disease
Obstructive jaundice
Cirrhosis
Clotting issues
Consider withdrawls
Hematologic Disorders
Anemia- poor H&H
Sickle cell disease- complicated pain management. Bad is disordered- > crisis clotting
G6PD deficiency- (inc rbc breakdown)
factor 5 leidan in pregnant women (inc clotting) - schedule anticoags ahead of time
Coagulopathies- drug induced
Neurologic disease
Cerebrovascular disease- strokes
Seizure disorders
Multiple sclerosis- temperature sensitive- warm before
Aneurysm and AV malformation- consider high bp
Parkinson disease
Neuromuscular junction disorders- avoid nm blockers
Muscular dystrophy and myopathy
Sz meds shortens anesthetics- reduce by 2/3-3/4
Musculoskeletal and Connective tissue disorders
Rheumatoid Arthritis- immunotherapy and joint instability – atlantooccipital joint instability
Ankylosing Spondylitis- nm deficints. Ostepcomprmise.
Systemic Lupus Erythematosus
Raynaud Phenomenon- cold and lower bp= not good
Changes in bg or pain- cold and lower bp
Informed consent
Respect for pt autonomy
Duty to inform pts about the risks and alternatives to treatment, procedures, and consequences
Salgo v Trustees of Leland Stanford Hospital
Salgo v Trustees of Leland Stanford Hospital
1957 court case that helped to establish what the practice ofinformed consentwas supposed to look like in the practice of modernmedicine. This was evaluated with respect to theCalifornia Court of Appealscase where Martin Salgo sued the trustees ofStanford Universityand Stanford physician Dr. Frank Gerbode formalpracticeas he claimed that they did not inform him nor his family of the details and risks associated with anaortogramwhich left him permanentlyparalyzedin his lower extremities.
Shared decision making
Communicating with pts about the risks and benefits of possible interventions
Eliciting pts’ goals, values, and concerns
Assisting pts in how to conceptualize the risks and benefits/how to approach the decision
Hospital to hospital decision on psych pts
Diminished capacity –MR?- POA
Do whats in the pts best interest?
High quality decisions are based on what factors?
Right operation (clinical evidence)
Right provider (certification/ privleging)
Right Place (necessary resources)
Right patient (shared decision making)
Do-Not-Resuscitate Orders in thePerioperative Period
Full attempt at resuscitation
Limited attempt at resuscitation defined with regard to specific procedures
-May refuse certain/specific resuscitation procedures
-Anesthesia should inform pt/surrogate about which procedures are essential and not essential for the success of the anesthetic and proposed surgery
Limited attempt at resuscitation defined with regard to the pt’s goals and values
-Allows the anesthesia and surgical teams to use clinical judgment in determining appropriate resuscitation procedures
High surgical risk
> 5% for morbidity and mortality
aortic and major vascular
peripheral vascular
Intermediate surgical risk (1%-5%)
(1%-5%) for morbidity and mortality
Intrabdominal surgery
intrathoracic surgery
carotid endarterectomy
head/neck surgery
Low surgical risk
(<1%) for morbidity and mortality
ambulatory surgery
breast surgery
endoscopic procedures
cataract surgery
skin surgery
urologic surgery
orthopedic surgery
RCRI
revised cardiac risk index
Prediction tool recommended by ACC/AHA
Estimates risk of cardiac complications after surgery
components;
High risk surgery (intraperitoneal, intrathoracic, or supringuinal vascular procedure)above inguinal ligament*
ischemic heart disease
history of congestive heart failure
history of cerebrovasular disease
DM requiring insulin
creatinine > 2.0 mg/dl (176 umol/L)
score
0=0.4%
1=1%
2=2.4%
>3= 5.4%
Functional Capacity
Assessment of cardiopulmonary fitness
Estimates pt risk for major post-op morbidity or mortality
Determines if further testing is necessary
Poor functional capacity = increased peri-operative risk
Measured in METs (metabolic equivalent of task)
-Rate of energy consumption at rest
-1 MET = 3.5 mL/kg/min
->4 METs- cut off- Less than that consider why they aren’t doing okay
1- eating, working at computer, dressing
2- walking down stairs or in your house or cooking
3- walking 1 or 2 blocks on level ground
4- taking leaves, gardening
cant walk normally? = stress test
Emergency surgery
life or limb would be threatened if surgery did not proceed within 6 hours or less
Proceed directly to emergency surgery w/o pre-op cardiac assessment/ workup
Focus on surveillance (serial cardiac enzymes, hemodynamic monitoring, serial ECGs) and early treatment of any post-op CV complications
Gi bleed and active MI and trying to treat both at the same time.
Urgent Surgery
life or limb would be threatened if surgery did not proceed within 6 to 24 hours.
Time- sensitive surgery
delays exceeding 1 to 6 weeks would adversely affect patient outcomes. Screenings- ECG/ coloscopy’s
Anesthesia influences on poor perioperative outcome
provider characteristics
Errors in judgment
mishaps
Surgery components on poor perioperative outcomes
errors in judgement
Location of postoperative care
Poor perioperative outcomes
death, major morbidity, minor morbidity, readmission, satisfaction
ASA 1
normal healthy patient
healthy, non smoking no or minimal alcohol use
ASA 2
A patient with mild systemic disease
Mild diseases only without substantive functional limitations. Current smoker, social alcohol drinker, pregnancy, obesity (30<BMI<40), well-controlled DM/HTN, mild lung disease
ASA 3
A patient with severe systemic disease
Substantive functional limitations; One or more moderate to severe diseases. Poorly controlled DM or HTN, COPD, morbid obesity (BMI ≥40), active hepatitis, alcohol dependence or abuse, implanted pacemaker, moderate reduction of ejection fraction, ESRD undergoing regularly scheduled dialysis (PD), history (>3 months) of MI, CVA, TIA, or CAD/stents.
ASA 4
A patient with severe systemic disease that is a constant threat to life
Recent (<3 months) MI, CVA, TIA or CAD/stents, ongoing cardiac ischemia or severe valve dysfunction, severe reduction of ejection fraction (<40%), shock, sepsis, DIC, ARD or ESRD not undergoing regularly scheduled dialysis
ASA 5
A moribund patient who is not expected to survive without the operation
Ruptured abdominal/thoracic aneurysm, massive trauma, intracranial bleed with mass effect, ischemic bowel in the face of significant cardiac pathology or multiple organ/system dysfunction
ASA 5 e = emergent
ASA 6
A declared brain-dead patient whose organs are being removed for donor purposes
Pre op testing is done to…..
Testing is indicated if it can identify abnormalities, change the diagnosis and management plan, or the pt’s outcome
Tests should satisfy the following criteria to be useful
Diagnostic efficacy… correctly identify abnormalities?
Diagnostic effectiveness… change the diagnosis?
Therapeutic efficacy… change the management of the pt?- eval and treat pt
Therapeutic effectiveness… change the pt’s outcome?
CBC/Hemoglobin/Hematocrit
Surgery, potential blood loss, individualized pt clinical indications
Hx of increased bleeding, hematologic disorders, anti-coagulant therapy, poor nutritional status, septic
ASA-PS 3 or 4 undergoing intermediate-risk procedures- baseline
All pts undergoing major procedures- need baseline
Renal Function Testing
DM, HTN, cardiac disease, dehydration (N/V, diarrhea), renal disease, fluid overload. Metabolic derangement.
ASA-PS 3 or 4 undergoing intermediate-risk procedures
ASA-PS 2, 3, or 4 undergoing major procedures
GFR, BUN, Creat-
Electrolytes lab tests
Suspected undiagnosed or worsening condition that will affect peri-op management
Renal or hepatic disease, malnutrition, malabsorption, ETOH abuse, HF, arrhythmias, medications that may cause an imbalance
after dialysis
largest cause of arrhythmias- mag and K
Ectopy/ ekg changes- get chem
POC tests
ha and h. artery sample; ph, po2, pco2, bicarb, BD, K, cl, na, ca.
Liver Function Testing
Liver injury/disease and physical exam findings
Hepatitis, jaundice, cirrhosis, portal HTN, biliary disease, gallbladder disease, bleeding disorders. Abd blunt trauma, etoh consumption, meds.
GI bleed- liver figures in because of decreased clotting/ hepatic portal htn.
albumin if malnourished
Coagulation Testing
Known or suspected coagulopathy identified on pre-op evaluation
Known bleeding disorder, hepatic disease, and anticoagulant use
ASA-PS 3 or 4; undergoing intermediate, major, or complex surgical procedures; known to take anticoagulant medications or chronic liver disease
Coag- looks for bleeding gums/ petechia, hemorrhaging things, unexplained bruising, meds that cause coagulopathies.
PT/ INR- may be good but not good, may need PFT and teg.
Meds including aspirin get coag panel.
Talk to hem/onc and get coag testing. (provide recommendations)
Give ns before to dilute out hbg of 20 or pre screen and give unit of blood if the antibodies have to come from an outside area?
Serum Glucose and Glycated Hemoglobin (HbA1c)
Known DM (or family history), obesity (BMI > 50), cerebrovascular or intracranial disease, or steroids history
HbA1c long-term measurement of glucose control (3 months)
Better assessment of diabetic therapy > random/fasting blood sugar
HbA1c = ½ from previous 30 days + ½ the time period of 2 to 3 months before
All diabetic patients- know a1c and bg.
Urinalysis
Suspected UTI and unexplained fever or chills
Orthos/ total joint worry about UTI’s- high risk of infection- don’t want to get a UTI. Spilling infected urine on the joint.
Pregnancy Test
Pregnancy – anesthesia meds; benzos/ Nitric Oxide – given early in pregnancy = teratogenic- don’t want liability. Not monitoring baby if we don’t know its there. May need gal bladder out (elective)- fetal monitoring throughout procedure.
High risk of miscarriage if emergent surgery 50%. Surgical or traumatic stress. Get OB on early on.
Types of pregnancy tests- urine (easiest and cheapest), beta / quantitative HCG add on.—be sensitive
Causes of beta hcg = + tumor? – may be tracking beta HCG
Sexual activity, birth control use, and date of last menstrual period
Recommendation… all women of childbearing potential of the possibility of pregnancy and women possibly pregnant made aware of the risks of anesthesia/surgery to the fetus
ECG
Ischemic heart disease, HTN, DM, HF, chest pain, palpitations, abnormal valvular murmurs, dyspnea on exertion, syncope, arrythmia . <4.
Known IHD, significant arrhythmia, PAD, CV disease, significant structural heart disease undergoing intermediate- risk or high-risk procedures
Routine in ASA-PS 3 or 4 undergoing intermediate- risk
Routine ASA-PS 2, 3, or 4 major/high-risk procedures
Chest Xray
Based on abnormalities identified during pre-op evaluation
Advanced COPD, bullous lung disease, pulmonary edema, pneumonia, mediastinal masses, suspicious physical exam findings (rales, tracheal deviation), trauma.
Mass on trachea- may collapse trachea when nmb given. Wide mediastinum- may see aortic rupture, varices, esophagus rupture
Risk with broken ribs/flail chest
when anesthetized- hard to ventilate can cause a pneumothorax.
Chest/ pulmonary contusion ventilating and having trouble / high risk of pneumo- may not be seen on initial chest x ray.
Wide mediastinum
if high pressure bv (aorta) tears open or leaks makes that mediastinum space bigger. Esophagus rupture can also cause wide mediastinum
Wide mediastinum- may see aortic rupture, varices/ esophagus rupture
anorexia
CBC tree
wbc hbg/hct plat
Chem tree
na cl BUN glucose
k CO2 Creat
Coag tree
L = Pt
R = PTT
top= INR
GA
Total loss of consciousness and airway control
ET or LMA used- egd/ colonoscopy-
Ex: major surgeries… total joints, open-heart surgery, bowel surgery
IV/Monitored Sedation “mac” – monitored anesthesia care
Level of sedation ranges… minimal (drowsy, able to talk) to deep (sleeping, may not remember surgery/procedure
NC or face mask to oxygenate.
Ex: minor surgeries/procedures or shorter, less complex procedures… biopsy, colonoscopy
Regional
– peripheral nerve block,
Pain management method that numbs a large part of the body using a local anesthetic
Epidural or spinal
Ex: childbirth or joint replacements in elderly pts
Local
Pain management method, usually a one-time injection of local anesthetic that numbs a small area of the body
Can be used with general or conscious sedation depending on the surgery and pt history
Ex: skin or breast biopsy, bone/joint repair
Most common allergy agents
neuromuscular blockers- Roc
Antibiotics - PenG , cephlasporins
Chlorhexidine
Muscle relaxants are the most common, followed by latex, chlorhexidine, Abx and opioids.
Incidence of true anaphylaxis involving anesthesia
1:20000
Muscle relaxants are the most common causes, followed by latex, chlorhexidine, antibiotics and opioids (selective), iodine based solutions, adhesives (be aware of the tape).
Latex allergy is a concern for?
Spina bifida
Latex allergy
Risk factors – history of multiple surgeries, occupational exposure to latex (healthcare workers, food handlers/ condoms), food allergies that cross-react (mango, kiwi, avocado, passion fruit, banana, and chestnuts).
Notify surgical team immediately
ABX allergy
PCN and cephalosporins most common causes of anaphylaxis
Small risk of cross-reactivity, usually rashes
Avoid in true IgE –mediated allergy
Vancomycin… distinguish between allergy and “red man syndrome”
Histamine-induced side . Give antihistamines and give vanc slower
Cephazolin has a 10-15% risk of cross reactivity with pts that have PCN allergy- give test dose and see if they react. Usually not full blown rxn. Benedryl/ pepcid and test doses.
True anaphyalzis to pcn avoid cephazolin
Local anesthetics allergies
Amide vs ester
Ester reactions… due to preservative - para-aminobenzoic acid (PABA)
Epinephrine in LA causes adverse side effects, not an allergy
Lidocaine is amides have I’s in it. Lidocaid , pivicaidn. ”I” amide.
Neuromuscular blocking agents allergy
Quaternary ammonium compounds – where the rxn comes from.
Neostigmine and morphine may cause rxn. Neostigmine- given for a GA or have MG.
Cross-reactivity possible with allergy to neostigmine and morphine
Ammonium ions
Opioids allergies
True allergy is rare… related to side-effects (ex. nausea and vomiting)- avoid with pts with PONV- try premedicating- don’t give opioids use something else for pain management.
Antihypertensive meds pre operative
continue
Except angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), May d/c 24 hours before surgery- cause hypotension especially lisinopril under anesthesia.
Cardiac medications (ex. Beta-blockers, digoxin, amio) pre op
continue
core measure; if pt on beta blocker make sure its taken within 24 hours of surgery.
Anti-depressants, anxiolytics, and other psychiatric medications pre op
continue
Tricyclic anti-depressants… order an ECG d/t prolonged QT interval
Thyroid medications- pre op
continue
abruptly stopping can be traumatic
Oral contraceptive pills pre op
continue
High-risk pt for post-op venous thrombosis… d/c 4 weeks prior to surgery
Suggamadex may decrease effects of oral contraceptives. Use alternative contraceptive for 14 days after
Eye drops pre op
continue
Gerd meds pre op
continue -
dont want reflux/ aspiration
Opioid meds pre op
continue
dont want to get behind on pain
Anti-convulsant medications- pre op
continue
decrease life span of nmb
Asthma medications- pre op
continue
give tx before- Corticosteroids (oral and inhaled)
Statin medications- pre op
continue
increase cardiac risk if stop taking
Aspirin Pre op
why are they taking them?
Cont in pts w/ prior percutaneous coronary intervention, high-grade ischemic heart disease, significant cardiovascular disease,
Typically, d/c 10-14 days prior to surgery- wait for plat to die off
COX-2 inhibitor medications (celecoxib) pre op
continue
Unless concern regarding bone healing… may d/c prior to surgery
May give dose before
Monamine oxidase inhibitor (MAOIs) medications
pre op
continue
Adjust anesthesia plan to avoid meperidine (SZ or Serotonin syndrome) and in-direct acting vasopressors (ephedrine)(pt may not respond well to ephedrine)
ASA dc….
10-14 days before surgery
Clopidogrel, ticagrelor dc….
5-7 days
Prasugrel… d/c
7-10 days
Ticlopidine… d/c
10 days
P2Y12 inhibitors
(clopidogrel, ticagrelor, prasugrel, ticlopidine)
Do not d/c in drug-eluting stents until 6 months of dual antiplatelet therapy is completed*
Continue in pt for cataract sx w/ topical or general anesthesia*. GET PFT.
Stent- may need for it to continue- take pts off one and put on something we can reverse- lovenox -> heparin ( can reverse with protamine if they start bleeding)
Topical medications dc….
day of surgery – don’t want patch on there with electrical currents going through.
Diuretics dc….
day of surgery . Don’t want volume depleted before surgery
Thiazide diuretics should be continued- don’t want bp out of control
Sildenafil dc….
24 hours before surgery (may be before).
ED? – stop.
Taking it for pulm htn?- continue taking.
NSAID dc…
48 hours before surgery
Warfarin dc….
5 days before surgery . Usually stop and put on heparin
Continue in pt for cataract sx w/ topical or general anesthesia***
Post-menopausal HRT dc….
4 weeks prior to surgery
Non-insulin anti-diabetic medications dc…..
on day of surgery
SGLT2 inhibitors… d/c 24 hours before surgery
Pre op insulin
D/c short-acting (regular) on day of surgery
If an insulin pump, continue at basal rate
Type 1
Take a small amount (approx 1/3) of usual dose of morning long-acting insulin on day of surgery
Type 2
Take none or up to half of long-acting or combination insulin dose on day of surgery
Dm- what going on? meds they are taking and NPO status.
Pre-operative medication managementSteroids and HPA Suppression
Cortisol is produced by the adrenal gland
Hydrocortisone is an equally potent synthetic version
Exogenous glucocorticoids suppress cortisol secretion at HPA axis
May lead to adrenal insufficiency and adrenal atrophy – been taking steroids for so long
Adrenal recovery occurs gradually after steroid therapy is tapered and d/c’d
May blunt the normal cortisol hypersecretion associated with surgery
Taking steroid and doing fine until we induce stress and don’t respond because they’ve eaten up all that cortisol, treat by
Give meds that simulates adrenal gland/ release cortisol and don’t respond-> give dose of steroids- 100mg of hydrocortisone to get cortisol level up because taking steroids for so long they got used to it.
Long term steroids- adrenal wont respond to how they’re supposed to,
Steroids taken for ; pain or neuro muscular diseases, copd.
HPA Suppression
No HPA suppression with short duration, low-dose steroids – dexamethasone 4-8 mg for nausea and pain cocktail.
HPA suppression with >20 mg prednisone/day >3 weeks and in pts with Cushingoid appearance- hydrocortisone 100 mg- may stay on afterwards.
Pre-op
Assess duration, dose, and potency of all steroids taken during the past year
Stress dose
Physiologic replacement doses are required
Dosage varies based on surgical procedures
Stress dose steroids
Hydrocortisone 100 mg q8 hours
Echinacea (purple coneflower root)
activation of cell-mediated immunity
long term immunosuppressant
Ephedra (ma huang)
increases heart rate and bp through direct and indirect sympathomimetic effects
used to be taken for wt loss
try something other than ephedrine if not working
Garlic (ajo)
inhibts plat aggregation
increase fibrinolysis
equivocal anthypertesive activity
hold for 10-14 days
given to cardiac pts
Ginger
antiemetic
antiplat- increased risk of bleeding
aggregation
Ginkgo (duck-foot tree, maiden hair tree, silver apricot)
inhibits plat- activating factor
Ginseng
lowers bg, inhibits plat aggregation, increase pt/ptt
green tea
inhibit plat aggregation, inhibits TXA2 formation
KAVA (pepper)
sedation/ anxiolysis
Saw palmetto
inhibits 5alpha reductase
inhibits cyclooxygenase
st johns wort
inhibits nt reuptake
mao inhibition unlikely
can cause seratonin sydrome
Valerian
sedation
NPO 8 hours
full meal
full meal, fatty foods , enternal tf not post pyloric
Diabetic/ gastric reflux pts have delayed gastric emptying- so wait 8 hours.
NPO 6 hours
Light meal
toast, and liquids, infant formula, nonhuman milk , coffee with milk
NPO 4 hours
Breast milk
NPO 2 hours
clear liquids
water, sports drinks, carbonated bev, coffee, tea, juice w/o pulp
Mendelson syndrome
increased risk of aspiration
>25 mL gastric residual volume
pH <2.5- acidic substance
Aspiration prophylaxis
Decrease gastric volume and acidity – npo and give meds that reduce acid content (bicitrate/ sodium citrate) - raises gastric PH (tastes horrible)
Non-particulate antacids (sodium citrate)… increase gastric pH
Histamine-2 receptor antagonists (ranitidine, cimetidine, famotidine… increase gastric pH, decrease gastric acid secretion
Proton pump inhibitors (omeprazole, pantoprazole)… increase gastric pH, decrease gastric acid secretion
Dopamine-2 antagonist (metoclopramide)… reduces gastric volume
Curtis Lester Mendelsons
original 1946 description of his namesake syndrome, chemical pneumonitis was described in young and healthy obstetrical patients following aspiration of gastric acid under anesthesia. The standard use of regional anesthesia for most laboring women and increased awareness among anesthesia providers regarding the high risk of aspiration and potential difficult airway management in parturients has increased the safety in this population. This complication of anaesthesia led, in part, to the longstandingnil per os(abbr. NPO; a Latin phrase meaning nothing by mouth) recommendation for women in labour
Risk factors for pulm aspiration
hx of incompetense of lower esophageal sphincter w/ reflux
active n/v
symptomatic hiatal hernia
pregnancy
esophageal and gastric motility disorders
dm (poorly controlled or with gastroparesis)
significant opioid use
nm disorders (ALS(amyotrophic lateral sclerosis)/ parkinsons) and muscular dystrophies
AMS/ acute head injury
morbid obesity (BMI >40)
intra-abdominal masses, abd compartment syndrome
acute abdomen
bowel obstruction
emergency surgery
acute trauma
hx of gastric sx (gastrectomy, bariatric sx)
Apfel score
PONV risk scoring
female gener
history of ponv/ motion sickness
non smoking status
postoperative opioids