Coags Flashcards
Intima factors
endothelial layer
vwf
tissue factor
prostacyclin
no
media factors
subendothelial layer
collagen
fibronectin
Undamaged endothelium does not express
Tissue factor or collagen
Endothelial cells modulate hemostasis by synthesizing and secreting:
Procoagulants (initiators of coagulation)
Anticoagulants (inhibitors of coagulation)
Fibrinolytics (to dissolve the clot)
Endothelial cells release mediators….
Vasoconstrictors
Vasodilators- NO
von Willebrand factor (vWF) do what….
Adherence of platelets to the subendothelial layer
Tissue factor does what
Activates the clotting cascade pathway when injury to the vessel occurs
Some of these mediators control blood flow by vasoconstriction
thromboxane A2, adenosine diphosphate [ADP])
control blood flow by vasodilation
nitric oxide, prostacyclin
Coagulation factors function
Coagulation
Collagen function
Tensile strength
Fibronectin function
Mediates cell adhesion
Thrombomodulin function
Regulates anticoagulation pathway
Antithrombin III function
Degrades factors XII, XI, X, IX, II
Tissue pathway factor inhibitor function
Inhibits tissue factor
Plasminogen function
Converts to plasmin
tPA function
Activates plasmin
Urokinase function
Activates plasmin
Vasoconstiction mediators
serotonin, Thromboxane A2
adenosine diphosphate
Nitric Oxide function
Vasodilates, promotes smooth muscle relaxation
Prostacyclin function
Vasodilates, inhibits aggregation, promotes smooth muscle relaxation
media collagen function
A potent and important stimulus for platelet attachment to the injured vessel wall
media fibronectin function
Facilitates the anchoring of fibrin during the formation of a hemostatic plug
Adventitia Controls blood flow by ….
influencing the vessel’s degree of contraction