H2 antagonists antiulcer agents Flashcards
1
Q
Stimulation of which 3 agonists cause the parietal cells to secrete gastric acid?
A
Gastrin, acetylcholine, and H2 receptor
2
Q
What will inhibiting the H2 receptor cause?
A
Decreases gastric acid bc the stimulation of histamine increases gastric acid secretion
3
Q
Will inhibiting the H2 receptor competitively inhibit ALL gastric acid? why?
A
No, because you still have gastrin and acetylcholine stimulating gastric acid release
4
Q
What was the first H2 antagonist drug
A
cimetidine
5
Q
Difference in binding to H1 and H2 receptors
A
H1 - doesn’t require an imidazole ring
H2 - does require an imidazole ring
6
Q
Where, on an agonist molecule, would you add extra functionality to make it an antagonist
A
On the alpha-N
