H2 and PPI

Question 1

antacid ex

Answer 1

tums, Maalox, Mylanta

Question 2

antacid AE

Answer 2

milk alkali syndrome: hypercalcemia, alkalosis and renal impairment

Question 3

Histamin antagonists

Answer 3

Rantidine
Famotidine
Cimetidine
NIzatidine

Question 4

Histamine AE

Answer 4

very safe….rarely: renal and hepatic toxicity

crosses BBB and placenta: pregnant women should be careful

Question 5

PPI MOA

Answer 5

block acid secretion by binding and inhibiting H-K ATPase pump on luminal surface of parietal cells

Question 6

PPI drugs

Answer 6

Omeprazole, lansoprazole,reabeprazole, panoprazole

Question 7

PPI AE

Answer 7

very rare.. and mile: diarrhea, headach, drowsiness, muscle pain, constipation

Question 8

PPI drug interactions

Answer 8

metabolyized by cyp 450: decreased met of benzos, warfarin, and phenytoin
reduced absorption of ketoconazole and increased absorption of digoxin
prolonged can result in vit b12 def

Question 9

sucraflate MOA

Answer 9

polymerize and bind to necrotic tissue…creating barrier btwn gastric contents and mucosa