H pylori

Question 1

Gram what?

Answer 1

-

Question 2

Catalase, oxidase, urease?

Answer 2

+

Question 3

Spread route?

Answer 3

Fecal-Oral

Question 4

Function of flagella?

Answer 4

Follow pH chemotaxis to stay near higher pH by the mucosa

Question 5

Urease function?

Answer 5

Neutralize pH

Question 6

Mechanisms of disease?

Answer 6

Toxin production

Immune-mediated

Question 7

VacA function?

Answer 7

Pore forming toxin that allows Ca leakage

Question 8

CagA function? Binds what?

Answer 8

Pro-inflammatory toxin

Binds T4SS

Question 9

Gold standard for diagnosis?

Answer 9

Endoscopy + biposy with rapid urease test and culture

Question 10

Problem with gold standard?

Answer 10

Invasive and expensive

Question 11

Other tests that indicate ACTIVE infection?

Answer 11

Urease Breath Test

Stool Antigen Test

Question 12

Problem with blood antigen test?

Answer 12

Doesn’t indicate ACTIVE infection

Question 13

Burning epigastric ache, nausea, vomiting, “fullness” after eating?

Answer 13

Gastritis

Question 14

Gastric Ulcer pathogenesis?

Answer 14

Normal immune response (Not toxins)

Question 15

When are gastric ulcers the worst?

Answer 15

At night
Between eating (Relieved by eating)

Question 16

What tumors can be caused by H pylori?

Answer 16

MALToma
Gastric Carcinoma (Epithelial cell)