GynOnc Flashcards
HPV genotypes are associated with which genes in Cervical Cancer?
E6->
E7->
E6-> p53
E7-> Rb
HPV types associated with Cervical cancer
HPV 16 and 18 are responsible for 70%
HPV subtypes associated with condyloma
HPV 6 and 11
Surgery needed for cervical cancer that is <3 mm in Depth?
Simple hysterectomy
Surgery needed for cervical cancer invasive between 3 and 5 mm
Stage IA2-> Radical Hysterectomy with LN dissection
At what point do you switch from primary surgery to primary chemoRT for cervical cancer
Stage IB3-IVa gets chemoRT (>/= 4cm in greatest dimension)
Who gets post-op chemo/RT in cervical cancer (3)
Pos Margin
Positive LNs
Parametrial involvement
Need to give Cis and brachytherapy
1st line chemo for metastatic cervical cancer
carbo/taxol+avastin
Need to be careful about fistulas with addition of bevacizumab
Cutoff for invasion in Urterine cancer between IA and IB and Stage II
1A-> No invasion to <1/2 of myometrium
1B-> >1/2 of myometrium
2-> Invades cervical stroma but no extension past the uterus
Who gets adjuvant brachytherapy in Endometrial Cancer?
Grade I, stage IB
Grade II-II Stage IA
Who gets adjuvant EBRT in uterine cancer?
Grade III, Stage IB and higher
Treatment for Stage III Endometrial
IIIA/B-> Chemo +/- XRT
IIIC-> Chemo/RT + adjuvant carbo/taxol x 4
What gets you up to stage IIIC Endometrial Cancer
Positive nodes
IIIA-> serosa or adnexal involvement
IIIB-> vaginal or parametrial involvement
What Uterine cancer subtype can benefit from everolimus/letrozole combination?
Endometrioid type tumors
Which uterine cancer subtype is most likely to harbor HER2 mutations
SEROUS carcinoma.
Add trastuzumab to Carbo/Taxol in HER positive metastatic tumors
