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Onc Boards > GI > Flashcards

GI Flashcards

1
Q

1st mutation seen in development of pancreas cancer

A

KRAS

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2
Q

What is the degree cutoff for resectability in pancreas cancer

A

<180 degrees of major artery/vein or celiac plexus

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3
Q

What was the benefit of olaparib in pancreas cancer

A

Platinum sensitive disease resonding/stable after 16 weeks on treatment. Olaparib prolonged PFS by 3.6 months over placebo

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4
Q

What is adjuvant therapy for completely resected GB cancer

A

Cape x 8 cycles. Proven PFS benefit. No statistically significant OS benefit

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5
Q

What kind of drug is Pemigatinib?

When is it indicated?

A

FGFR2 inhibitor

2nd line therapy for biliary tract cancer

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6
Q

Which nodes are end point for local nodes in EGJ cancer?

A

Celiac nodes. Included in D2 resection

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7
Q

Preferred treatment locally advanced Esophageal SCC, Esophageal Adeno and GEJ adeno?

A

Chemo/RT-> Surgery

NO GASTRIC

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8
Q

Which locally advanced Gastro-Esophageal cancer group is not included in FLOT trial

A

Squamous

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9
Q

When do you need adjuvant chemo/RT in stomach/EGJ adenocarcinoma?

A

When there was a D1 resection (5FU based)

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10
Q

What are two aspects of imaging seen with HCC?

A

Arterial hypervascularity
Delayed Venous phase washout

In CIRRHOTIC livers

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11
Q

What are transplant qualifications for HCC (4)

A

Non-metastatic
No vein involvement
1 tumor up to 5 cm
3 tumors all less than 3 cm

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12
Q

Exclusion criteria for RFA (3)

A

Lesion >4cm
Child Pugh C
Near major vessel

NOT the case for TACE

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13
Q

Starting dose for Sorafenib in HCC

A

200 mg BID and titrate up

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14
Q

Cutoffs for +3 in ChildsPugh Score:
Albumin->
Bilirubin->
INR->

A

Albumin-> <2.8
Bilirubin-> >3
INR-> >2.2

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15
Q

Which Lynch mutation is mutually exclusive with BRAF mutation

A

MLH1. If MLH1 loss, check BRAF. If BRAF present, MLH1 is methylated, not mutated

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16
Q

What is high risk stage II colon cancer (5)

A 
T4 tumor
<12 LNs removed
Obstructed/perforated
LVI/PNI
Poorly differentiated
17
Q

Who does well with 3 mos of CAPOX as adjuvant therapy with colon cancer? (e.g. can be spared 6 months of FOLFOX)

A

Low Risk (t1-3n1)

18
Q

Which stage II colorectal tumors should NOT get adjuvant treatment

A

MMR-D

19
Q

Who can be spared Oxaliplatin in adjuvant space for colorectal cancer?

A

Age >70

20
Q

What chemo is used with neoadjuvant RT in rectal cancer

A

Cape or 5-FU, no oxaliplatin needed

21
Q

Which side colon cancer is more likely to benefit from cetuximab/panitumumab?

A

LEFT sided

RAS wild type

22
Q

What is combo regimen for BRAF mutated colon cancer in second line?

A

Encorafenib + Cetuximab

23
Q

What systemic treatment should be avoided in patients going for resection of liver met in colon cancer?

A

Cetuximab. It is harmful

24
Q

Who gets adjuvant chemotherapy following Chemo/RT for anal cancer?

A

No one

Onc Boards (6 decks)

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