GWAS lecture

Question 1

Monogenic

Answer 1

mendelian
1 gene

Question 2

multigenic

Answer 2

more than one gene but not many

Question 3

polygenic

Answer 3

many genes

Question 4

Relationship between association and causality

Answer 4

they do not equal each other

Question 5

The ability to detect associations depends on

Answer 5

how many loci
the effect size and allele frequency
sample size
the nature of markers used
heterogeneity of the trait

Question 6

GWAS stands for

Answer 6

genome wide association study

Question 7

What is a P value

Answer 7

the probability of obtaining test results at least as extreme as the results actually observed

Question 8

The P value was never intended to

Answer 8

be a substitute for scientific reasoning

Question 9

Linkage disequilibrium

Answer 9

the non-random association of alleles at different loci in a given population

Question 10

The GWAS Manhattan plot does better with

Answer 10

more data
-the data is whispering vs. shouting

Question 11

power is influenced by

Answer 11

sample size
distribution of effect size
frequency
Linkage disequilibrium

Question 12

Success is determined by

Answer 12

how many loci
genetic architecture
sample size
number of variants
heterogeneity of trait

Question 13

Complex traits are almost always due to

Answer 13

many genes, each with potentially many variants
thus, the effect of any one is small