Encode and Comparative Genomics

Question 1

preferred method for Encode

Answer 1

ATAC-seq

Question 2

how is it that humans have about the same number of protein coding genes as simpler organisms but are more complex

Answer 2

number of introns
alternative splicing

Question 3

comparative genomics

Answer 3

field in which researchers use a variety of tools to compare the complete genome sequences of different species

Question 4

resources needed to make species comparisons

Answer 4

reference genome
predicted genes
sequence information
-transcriptome
-genome

Question 5

To use comparative genomics you must first need

Answer 5

complete copy genomes

Question 6

Researchers choose the

Answer 6

appropriate time-scale of evolutionary conservation for the question asked

Question 7

to measure gene change you must start with

Answer 7

sequence alignment

Question 8

The process of domestication alters

Answer 8

regional features of the genome as estimated from sequence variation

Question 9

psuedogene

Answer 9

DNA sequence that resembles a gene but has been mutated into an inactive form over the course of evolution

Question 10

Organisms process mutations differently based on

Answer 10

phenotypic effect

Question 11

Types of mutations

Answer 11

harmful
beneficial
neutral

Question 12

What is needed for computational genomics

Answer 12

long reads to assemble reference genome
annotate the reference
measure

Question 13

two key comparative genomics narratives

Answer 13

what DNA feature is most often used to compare within and between species
what RNA feature is most often used to compare within and between species