Gut Microbiome Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

___ serotonin produced in gut by micro biome

A

70%

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2
Q

Ways in which gut microbiota cause disease

A
  1. Production of microbial metabolites (tryptophan+ short chain fatty acids)
  2. Influence immune system and production of pro-inflammatory cytokines
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3
Q

Dysbiosis

A

Disruption of gut
Microbiota composition

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4
Q

Which neurotransmitter’s function is affected with dysbiosis??

A

Serotonin, dopamine, gamma-aminobutyric acid (GABA)

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5
Q

Alpha-synuclein protein

A

Found in clumps called “Lewy bodies” in brains of individuals with PD , produced by GUT bacteria and travels to brain via vagus nerve

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6
Q

Proteins present in brain during Alzheimer’s disease

A

Tau protein, Amyloid-beta (forms sticky plaques in brains of individuals with AD)

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7
Q

In PD it is found that

A

Sodium butyrate ameliorated locomoter impairment and early motility

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8
Q

Increased propionate involves in (from PD experiments)

A

Neuroprotection by triggering Free Fatty Acid Receptors (FFAR) in enteric neurons

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9
Q

What does oral administration of Berberine do in mouse?

A

Increase DA production
Improves PD
Reduce 6-ODHA-induce- dopaminergic neuron loss
Improve motor deficits

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10
Q

In therapeutic application of Alzheimer’s disease study is done on

A

8 month old Th-APP/PS1 transgenic mice

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