Gut Microbiome

Question 1

___ serotonin produced in gut by micro biome

Answer 1

70%

Question 2

Ways in which gut microbiota cause disease

Answer 2

1. Production of microbial metabolites (tryptophan+ short chain fatty acids)
2. Influence immune system and production of pro-inflammatory cytokines

Question 3

Dysbiosis

Answer 3

Disruption of gut
Microbiota composition

Question 4

Which neurotransmitter’s function is affected with dysbiosis??

Answer 4

Serotonin, dopamine, gamma-aminobutyric acid (GABA)

Question 5

Alpha-synuclein protein

Answer 5

Found in clumps called “Lewy bodies” in brains of individuals with PD , produced by GUT bacteria and travels to brain via vagus nerve

Question 6

Proteins present in brain during Alzheimer’s disease

Answer 6

Tau protein, Amyloid-beta (forms sticky plaques in brains of individuals with AD)

Question 7

In PD it is found that

Answer 7

Sodium butyrate ameliorated locomoter impairment and early motility

Question 8

Increased propionate involves in (from PD experiments)

Answer 8

Neuroprotection by triggering Free Fatty Acid Receptors (FFAR) in enteric neurons

Question 9

What does oral administration of Berberine do in mouse?

Answer 9

Increase DA production
Improves PD
Reduce 6-ODHA-induce- dopaminergic neuron loss
Improve motor deficits

Question 10

In therapeutic application of Alzheimer’s disease study is done on

Answer 10

8 month old Th-APP/PS1 transgenic mice