Gut Microbiome Flashcards
___ serotonin produced in gut by micro biome
70%
Ways in which gut microbiota cause disease
- Production of microbial metabolites (tryptophan+ short chain fatty acids)
- Influence immune system and production of pro-inflammatory cytokines
Dysbiosis
Disruption of gut
Microbiota composition
Which neurotransmitter’s function is affected with dysbiosis??
Serotonin, dopamine, gamma-aminobutyric acid (GABA)
Alpha-synuclein protein
Found in clumps called “Lewy bodies” in brains of individuals with PD , produced by GUT bacteria and travels to brain via vagus nerve
Proteins present in brain during Alzheimer’s disease
Tau protein, Amyloid-beta (forms sticky plaques in brains of individuals with AD)
In PD it is found that
Sodium butyrate ameliorated locomoter impairment and early motility
Increased propionate involves in (from PD experiments)
Neuroprotection by triggering Free Fatty Acid Receptors (FFAR) in enteric neurons
What does oral administration of Berberine do in mouse?
Increase DA production
Improves PD
Reduce 6-ODHA-induce- dopaminergic neuron loss
Improve motor deficits
In therapeutic application of Alzheimer’s disease study is done on
8 month old Th-APP/PS1 transgenic mice