Dark DNA Flashcards
Small ncRNAs examples
miRNAs, small interfering RNAs (siRNA), P-element induced wimpy testis (PIWI)-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs)
HPA
Hypothalamic pituitary adrenal axis, central stress response system
miR-34c
Targets corticosteroid type 1 receptor and facilitates the recovery process following stressful situations
Results of exposing rats to mild restraint stress for 2 weeks
miR 186 and 381: overexpressed
miR-709: Under expressed
miRNA-132 and mi-RNA-128
Affect stress by targeting brain-derived neurotrophic factor gene
miRNAs which play opposite role (reduce stress)
miR-34b and miR-27a, associated with CRHR1
Role of GAS5
Interacts with glucocorticoid receptors
Interferes with binding of glucocorticoid response element (GRE) to DNA and inhibits it’s transcriptional activity
GAS5
Growth Arrest Specific Transcript 5
Stress levels of medical students significantly associated with
miR-16 levels
__ expression is reduced in individuals with PTSD
miR-125a
Blood levels of micro RNAs associated with panic and phobic disorders
miR-22, 138-2, 148a, 339, 488, 491
miR-223
Neuroprotective agent after a stroke, minimizes death of neuronal cells following an ischemic attack
GC receptors are targeted by
miR-18A and miR-124