Dark DNA Flashcards

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1
Q

Small ncRNAs examples

A

miRNAs, small interfering RNAs (siRNA), P-element induced wimpy testis (PIWI)-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs)

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2
Q

HPA

A

Hypothalamic pituitary adrenal axis, central stress response system

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3
Q

miR-34c

A

Targets corticosteroid type 1 receptor and facilitates the recovery process following stressful situations

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4
Q

Results of exposing rats to mild restraint stress for 2 weeks

A

miR 186 and 381: overexpressed
miR-709: Under expressed

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5
Q

miRNA-132 and mi-RNA-128

A

Affect stress by targeting brain-derived neurotrophic factor gene

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6
Q

miRNAs which play opposite role (reduce stress)

A

miR-34b and miR-27a, associated with CRHR1

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7
Q

Role of GAS5

A

Interacts with glucocorticoid receptors
Interferes with binding of glucocorticoid response element (GRE) to DNA and inhibits it’s transcriptional activity

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8
Q

GAS5

A

Growth Arrest Specific Transcript 5

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9
Q

Stress levels of medical students significantly associated with

A

miR-16 levels

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10
Q

__ expression is reduced in individuals with PTSD

A

miR-125a

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11
Q

Blood levels of micro RNAs associated with panic and phobic disorders

A

miR-22, 138-2, 148a, 339, 488, 491

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12
Q

miR-223

A

Neuroprotective agent after a stroke, minimizes death of neuronal cells following an ischemic attack

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13
Q

GC receptors are targeted by

A

miR-18A and miR-124

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