Dark DNA

Question 1

Small ncRNAs examples

Answer 1

miRNAs, small interfering RNAs (siRNA), P-element induced wimpy testis (PIWI)-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs)

Question 2

HPA

Answer 2

Hypothalamic pituitary adrenal axis, central stress response system

Question 3

miR-34c

Answer 3

Targets corticosteroid type 1 receptor and facilitates the recovery process following stressful situations

Question 4

Results of exposing rats to mild restraint stress for 2 weeks

Answer 4

miR 186 and 381: overexpressed
miR-709: Under expressed

Question 5

miRNA-132 and mi-RNA-128

Answer 5

Affect stress by targeting brain-derived neurotrophic factor gene

Question 6

miRNAs which play opposite role (reduce stress)

Answer 6

miR-34b and miR-27a, associated with CRHR1

Question 7

Role of GAS5

Answer 7

Interacts with glucocorticoid receptors
Interferes with binding of glucocorticoid response element (GRE) to DNA and inhibits it’s transcriptional activity

Question 8

GAS5

Answer 8

Growth Arrest Specific Transcript 5

Question 9

Stress levels of medical students significantly associated with

Answer 9

miR-16 levels

Question 10

__ expression is reduced in individuals with PTSD

Answer 10

miR-125a

Question 11

Blood levels of micro RNAs associated with panic and phobic disorders

Answer 11

miR-22, 138-2, 148a, 339, 488, 491

Question 12

miR-223

Answer 12

Neuroprotective agent after a stroke, minimizes death of neuronal cells following an ischemic attack

Question 13

GC receptors are targeted by

Answer 13

miR-18A and miR-124