Guillain Barré Syndrome Flashcards
Guillain-Barre syndrome (GBS) describes an immune mediated demyelination of the peripheral nervous. What is the incidence of GBS?
1 - 1000 / 100,000
2 - 100 / 100,000
3 - 10 / 100,000
4 - 1 / 100,000
4 - 1 / 100,000
Guillain-Barre syndrome (GBS) describes an immune mediated demyelination of the peripheral nervous. Typically, what age does GBS typically peak?
1 - 5-10
2 - 20-30
3 - 40-50
4 - 70-80
2 - 20-30
BUT can occur at any age
Rare in children
Guillain-Barre syndrome (GBS) describes an immune mediated demyelination of the peripheral nervous. Is GBS more common in men or women?
- men
3:2 ratio
Guillain-Barre syndrome (GBS) describes an immune mediated demyelination of the peripheral nervous. Is GBS typically an acute or chronic conditoon?
- acute
Also called Acute Inflammatory Demyelinating Polyradiculoneuropathy (AIDP)
Polyradiculoneuropathy = Diseases characterised by injury or dysfunction involving multiple peripheral nerves and nerve roots
Infection often precedes Guillain-Barre syndrome (GBS) (although not always), but what infection is most common associated with causing GBS?
1 - Cytomegalovirus
2 - Epstein Barr Virus
3 - Campylobacter jejuni
4 - Influenza
5 - HIV
3 - Campylobacter jejuni
Can also occur following vaccination
Infection often precedes Guillain-Barre syndrome (GBS) (although not always), with Campylobacter jejuni being the most associated with GBS. Typically GBS occurs within how long post infection?
1 - <12 weeks
2 - <6 weeks
3 - <4 weeks
4 - <1 week
3 - <4 weeks
Which 2 of the following are the typical signs of Guillain-Barre syndrome (GBS)?
1 - worsening ascending weakness
2 - rigidity and hypertonia
3 - areflexia
4 - hypereflexia
1 - worsening ascending weakness
3 - areflexia (lack of reflexes)
Both of these are LMN presentations
Is Guillain-Barre syndrome (GBS) a UMN or LMN demyelinating condition?
- LMN
Attacks Schwann cells
The most common flaccid paralysis causing condition and increasing for some reason
Guillain-Barre syndrome (GBS) typically presents with an ascending weakness (legs 1st then arms) and a lack of reflexes, common in LMN conditions. Are there major sensory symptoms?
- no
If present these symptoms are mild and can present like glove and stockings
In addition to the ascending weakness (legs 1st then arms) and areflexia (lack of reflexes), which of the following do patients NOT typically present with in Guillain-Barre syndrome (GBS)?
1 - back pain
2 - history of gastroenteritis or URTI
3 - cranial nerve involvement e.g. diplopia
4 - babinski sign
5 - autonomic involvement: e.g. urinary retention, diarrhoea
4 - babinski sign
Present in UMN lesions
Guillain-Barre syndrome (GBS) is though to be due to molecular mimicry, where pathogens imitate host antigens. Which of the following antibodies are most commonly associated with GBS?
1 - Anti-schwann antibodies
2 - Anti-ganglioside antibodies
3 - Anti-oligodeendroctes
4 - Anti-macularcytes
2 - Anti-ganglioside antibodies
Written as GM-1 and typically present in 25% of patients with GBS
Guillain-Barre syndrome (GBS) is though to be due to molecular mimicry, where pathogens imitate host antigens. Anti-ganglioside antibodies are most commonly associated with GBS. Are these useful in diagnosing patients?
- no
Typically present following the condition
Guillain-Barre syndrome (GBS) is typically a clinical diagnosis, with patients presenting with ascending weakness (legs 1st then arms) and areflexia (lack of reflexes) and mild sensory symptoms. A lumbar puncture could be performed to aid with diagnosis, but which of the following would be observed in GBS?
1 - high protein and high WBC
2 - high glucose and high WBC
3 - high protein and normal WBC
4 - low protein and high WBC
3 - high protein and normal WBC
May also be normal in early disease course
Nerve conduction studies (show demyelinating pattern) and imaging can be supportive
Miller Fisher syndrome (MFS) is a variant of Guillain-Barre syndrome (GBS). Although the following can present in a similar way to GBC, what is typically affected first in MFS compared to GBS?
1 - sensory affects
2 - upper limbs
3 - bulbar symptoms
4 - eye muscles
4 - eye muscles
MFS typically presents as a descending paralysis
Anti-GQ1b antibodies are present in 90% of cases
As patients with Guillain-Barre syndrome (GBS) experience neuropathic pain, which 2 of the following are most likely to be given to help with the pain?
1 - gabapentin
2 - amitriptyline
3 - sertraline
4 - carbamazepine
1 - gabapentin
4 - carbamazepine