GU Neoplastic Disorders Flashcards

1
Q

What is the most common renal neoplasm?

A

renal cell carcinoma

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2
Q

What is the most common renal malignancy in childhood?

A

Wilm’s tumor (nephroblastoma)

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3
Q

What is the most common type of bladder cancer?

A

transitional cell carcinoma

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4
Q

What is the most commonly diagnosed malignancy among 20-34 year old males?

A

testicular cancer

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5
Q

What is the 2nd most common cause of cancer death in men?

A

prostate cancer

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6
Q

Renal Cell Carcinoma Triad of Sxs

A
  • hematuria
  • flank pain
  • abdominal/flank mass
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7
Q

Dx of Renal Cell Carcinoma

A

-IVP/CT: often found incidentally on radiology studies

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8
Q

Tx of Renal Cell Carcinoma

A
  • early, aggressive surgical management provides best chance of cure
  • majority do not respond to standard chemo
  • surgery curative if non-metastatic
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9
Q

What is Wilm’s tumor (nephroblastoma)?

A
  • affects ages 1-5
  • develops in 1 or both immature kidney cells
  • genetic
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10
Q

Risk Factors for Wilm’s Tumor

A
  • aniridia (absence of iris)
  • cryptorchidism
  • hypospadius (abnormal urethral opening)
  • hemihypertrophy
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11
Q

Signs and Sxs of Wilm’s Tumor

A
  • increased abd size, hepatosplenomegaly
  • anemia, cardiac murmur
  • hematuria
  • decreased appetite, weight loss
  • asymptomatic
  • fever
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12
Q

Dx of Wilm’s Tumor

A

US/CT

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13
Q

Tx of Wilm’s Tumor

A
  • nephrectomy

- chemo or radiation

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14
Q

Risk Factors for Bladder Cancer

A
  • smoking #1
  • high fat diet, chronic low fluid intake
  • chronic lower UTI
  • chronic indwelling catheter
  • hx of pelvic irradiation
  • prostate cancer
  • schistosomiasis in Mediterranean
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15
Q

Sxs of Bladder Cancer

A
  • hematuria, urgency, frequency, dysuria
  • abdominal or pelvis pain or mass
  • wasting in systemic dz
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16
Q

Dx of Bladder Cancer

A
  • NMP22 bladder check (tumor marker in urine)

- urine cytology is most specific

17
Q

Tx of Bladder Cancer

A
  • transurethral resection
  • bladder replaced w/ part of colon
  • chemo/radiation
  • usually good prognosis
18
Q

Testicular Cancer Types

A
  • non-germinal (5%)

- germinal (95%): seminomas (slow growth) and non-seminomas (rapid growth)

19
Q

Risk Factors for Testicular Cancer

A
  • cryptorchidism (undescended testes)
  • family hx, increased maternal estrogen in utero
  • testicular atrophy
  • trauma to testicle
  • abnormal testicular development (eg Kleinfelter’s, Down’s)
  • Caucasian
20
Q

Sxs of Testicular Cancer

A
  • painless lump in testicle
  • dull ache in groin/low abdomen
  • may have hydrocele
  • infertility
21
Q

Dx of Testicular Cancer

A

US is gold stadnard

22
Q

Tx of Testicular Cancer

A
  • orchiectomy used for dx and tx
  • radiation/chemo
  • > 95% overall survival
23
Q

Who gets prostate CA?

A

-men over 50

24
Q

Risk Factors for Prostate CA

A
  • age > 50
  • positive family hx
  • race (AA increased risk)
25
Q

Signs and Sxs of Prostate CA

A
  • trouble voiding, weak stream
  • hematuria
  • weight loss
  • bone pain (w/ mets)
  • masses/firmness on DRE
26
Q

Dx of Prostate CA

A
  • UA
  • PSA > 4 ng/mL
  • CT
27
Q

Tx of Prostate CA

A
  • watchful waiting
  • chemo/radiation
  • prostatectomy
28
Q

What are some sequelae of prostatectomy?

A
  • urinary incontinence

- erectile dysfunction