Group F - Demyelinating disorders Flashcards
Diagnostic criteria, Neuroimaging, Variants, Treatments
This sign appears to suggest a diagnosis of multiple sclerosis at an earlier stage.
Q from Soller, T
Dot-Dash Sign
Set of guidelines that incorporate clinical and laboratory evaluations, as well as magnetic resonance imaging (MRI) data, to establish an MS diagnosis.
Q from Soller, T.
Mcdonald criteria
A 29-year-old woman developed pain in her eyes and visual difficulties, which resolved over a period of months. Nine months later she started having balance problems, clumsiness, hand weakness and fatigue. CSF analysis showed elevated gamma globulin and oligoclonal bands were present after electrophoresis. Which of the following is the most likely diagnosis?
-Guillain-Barre syndrome
-progressive multifocal -leukoencephalopathy
-granulomatous meningitis
-multiple sclerosis
Q. From Shanmugam Raghunathan, Praveen
Multiple sclerosis
Which of the following best describes the pathological changes in multiple sclerosis?
A, sharply delineated areas of demyelination with many axons remaining intact.
B. diffuse regions showing loss of axons, myelin sheaths and glia.
C. loss of astrocytes in cortical areas.
D. demyelination of peripheral nerves
Q from Shanmugam Raghunathan, Praveen
A, sharply delineated areas of demyelination with many axons remaining intact
symmetrical bilateral plaque measuring at least 3 × 4 involving ____________? (SHAIK NAFEES)
A, Centrum semiovale
B. Cerebral white matter
C. Semioval center
D. All the above
A, Centrum semiovale
Oligodendrocytes and schwann cells are specialized glial cells that generate the myelin sheaths in ?
1.CNS
2.PNS
3.ANS
A, 1 AND 2
B. 2 AND 3
C. 1 AND 3
D. ONLY IN 1
(From SAITEJA SATHYAVETI)
A, 1 AND 2
Multiple
sclerosis affects the central nervous system (CNS). Which part of the CNS is usually attacked
A. Neurons
B, Myelin
C. Plaques
D. Vertebrae
(From SAITEJA SATHYAVETI)
B, Myelin
In Marburg disease imaging shows diffusely disseminated disease are? (SHAIK NAFEES)
A. Large cavitating lesions
B. Incomplete enhancing rim
C. Multiple other patchy enhancing foci
D, All the above
D, All the above
This MS treatment inhibit lymphocytes proliferation and the synthesis of most pro- inflammatory cytokines.
a. Natalizumab
b. Galtiramer acetate
c, Methylprednisolone
d. B-interferon
(Q from Sharma Aarthi)
C, Methylprednisolone
In MS imaging which one of the following shows multiple ovoid subcortical and deep periventricular hyperintensities?
a. Dot-Dash sign
b, Dawson’s fingers
c. Flair
d. T2
(Q from Sharma Aarthi )
B, Dawson’s Fingers
To fullfill a diagnosis of MS based on the 2017 McDonald criteria, an individual must have the following:
A. Evidence of CNS damage disseminating in space
B. Evidence of neurological damage that is disseminating in time
C, Both are correct
D. None of the above
Q from Sakiting, Alfe Dasa D.
C, Both are correct
Based on the McDonald criteria in diagnosing MS, this refer to neurological damage that occured in at least two regions in the brain and/or spinal cord.
A. Dissemination in time
B, Dissemination in Space
C. Both are correct
D. None of the above
Q from Sakiting, Alfe Dasa D.
B, Dissemination in space
Acute Hemorrhagic Leukoencephalitis also known as
a, Weston Hurst disease
b)retinocochleocerebral vasculopathy
c) Tarsal tunnel syndrome
d) Morton’s neuroma
(Q from
Senthilkumar, Akshara Sree)
a, Weston Hurst disease
Neuroimaging of brain in _____ has Hazy flocculent “cotton balls” and Bilateral but asymmetric white matter lesions.
a. Acute Hemorrhagic Leukoencephalitis
b, Acute Disseminated Encephalomyelitis ( ADEM)
c. Susac syndrome (SICRET)
d. Neuromyelitis Optica Spectrum Disorder (NMOSD)
(Q from Senthilkumar, Akshara Sree)
b, Acute Disseminated Encephalomyelitis (ADEM)
AA 38-year-old woman with multiple sclerosis (MS) has stable neurologic deficits resulting from old
demyelinated plaques. Which of the following histopathologic features would be prominent in this patient’s old plaques?
(Senthilkumar, Sneha)
A. Complete loss of axons
B, Gliosis
C. Histiocytic infiltration
D. Lymphocytic infiltration
E. Myelin breakdown
B, Gliosis
