Group E - Demyelinating disorders Flashcards
Neuroanatomic correlates, Epidemiology, Risk factors, Pathology, Clinical presentation, Clinical subtypes
CNS-Oligodendrocytes: PNS-?
Q from Rivera, Shaznae Keisha
Schwann Cell
Pathologic HALLMARK of Multiple Sclerosis (MS) is multiple focal areas of myelin loss within the CNS is called
Q from Rivera, Shaznae Keisha
Plaques or Lesion
A person with MS who wants to have children should be aware that her disease may affect her pregnancy in what way?
A. A miscarriage is more likely
B. Labor and delivery may be more risky
C. The baby may develop birth defects
D, MS symptoms may ease or fade away late in pregnancy but may get worse after childbirth
RADHAKRISHNAN DEEPIKA
D, MS symptoms may ease or fade away late in pregnancy but may get worse after childbirth
Myelination progresses In what direction from brain stem?
A.Rostrocranial
B,Caudocranial
C.craniocaudal
D.Anterior to posterior
Qfrom:
Purushothaman,Deepika
B,Caudocranial
Which therapy is often recommended for treating slowly progressing MS?
A. Corticosteroids such as prednisone
B. The hormone ACTH
C. Antibiotics
D. A and B
E, None of the above
RADHAKRISHNAN DEEPIKA
E, None of the above
Which cranial nerves myelin is synthesised by Schwann cells
A, Cranial nerve III-XII
B. Cranial nerve 1
C. Cranial nerve 2
D. Cranial nerve 7
Qfrom:
Purushothaman,Deepika
A, Cranial nerve III-XII
Multiple Sclerosis affects the central nervous system (CNS). Which part of the CNS is usually attacked?
A. Nerve cells (neurons)
B, Myelin
C. Plaques
D. Vertebrae
Q from : RAMESH, SHIVA
B, MYELIN
In a young adult patient with unexplained neurological deficits, which of the following do NOT suggest primary demyelinating disorder?
A. Diffuse or multifocal neurologic deficits
B. Sudden or subacute onset of deficits
C. Deficits that wax and wane
D, Slow, steady onset of symptoms
Qfrom: RAMESH, SHIVA
D, Slow, steady onset of symptoms
This is an ancillary symptom that has an electric-shock sensation that radiates down the back into the legs. This is supposedly caused by affectation of the spinal tracts particularly the posterior column. It may also occur in the cervical spondylosis.
A. Heat sensitivity
B, Lhermitte’s symptom
C. Paroxysmal symptom
D. None of the above
Q from Querubin, Aldous Clander
B, Lhermitte’s symptom,
It is an ongoing myelin breakdown associated with abundant macrophages containing lipid-rich, PAS- positive debris.
A, Active plaque
B. Inactive plaque
C. Light plaque
D. Shadow plaque
Q from Querubin, Aldous Clander
A, Active Plaque
Paroxysmal spasms can be treated with
A. carbamazepine
B. Ibuprofen
C. benzodiazepines
D, Option A and C
Q from Sagayaraj Gin Prakash Raj
D, Option A and C
Patients can have a broad spectrum of acute focal neurological symptoms including
A. Monocular visual loss
B. Diplopia
C. Gait disturbance
D, All of the above
Q from Sagayaraj Gin Prakash Raj
D, All of the above
The pathologic hallmark of multiple
sclerosis (MS) is multiple focal areas of
myelin loss within the CNS called plaques
or lesions. Plaques commonly occur adjacent to Which ventricles?
A, Lateral ventricle
B. third ventricle
C. Fourth ventricle
D. All the above
Q. Sriram prabhu
A, Lateral ventricle
Due to partial and
incomplete remyelination by surviving
oligodendrocytes
A, Partial plaque
B. Active plaque
C. Inactive plaque
D. Delimiting plaque
Q. Sriram prabhu
A. Partial plaque
A person with MS who wants to have children should be aware that her disease may affect her pregnancy in what way?
A. A miscarriage is more likely
B. Labor and delivery may be more risky
C. The baby may develop birth defects
D, MS symptoms may ease or fade away late in pregnancy but may get worse after childbirth
Q from Ramachandran Gowtham
D, MS symptoms may ease or fade away late in pregnancy but may get worse after childbirth
2.If symptoms and a physical exam suggest MS, how does a healthcare provider confirm it?
A. MRI
B. Spinal tap
C. Visual evoked potential (VEP) tests
D, All of the above
Q from Ramachandran Gowtham
D, All of the above
