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Immunology > Gross Structure of Antibodies > Flashcards

Gross Structure of Antibodies Flashcards

1
Q

What is another name of antibodies?

A

Immunoglobulins or IGs

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2
Q

What is the B cell receptor?

A

A membrane bound form of an antibody with the same structural features and same antigen specificity

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3
Q

What are the 5 classes or isotypes of antibodies?

A

IgA, IgD, IgE, IgG, and IgM

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4
Q

Epitope

A

A small specific area on a pathogen which is recognized by an antibody

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5
Q

The specificity of an antibody is determined by which region?

A

The variable region

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6
Q

The constant region determine what of an antibody?

A

Function

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7
Q

The constant region of an antibody determines what?

A

Function

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8
Q

What four polypeptide chains makeup an antibody molecule?

A

2 H chains and 2 L chains

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9
Q

What is the V region?

A

The N-terminus of each chain, known as the variable region

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10
Q

What is the C region of an antibody?

A

The rest of the H or L chain that differs only in determining isotype

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11
Q

What type of polymer is Igm?

A

Pentamer or hexamer

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12
Q

What type of polymer is IgA?

A

Dimer or monomer

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13
Q

What bonds hold together the H and L chains?

A

Disulfide

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14
Q

Which chains do not interact?

A

The two L chains

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15
Q

How many disulfide bonds hold the H chains together?

A

2

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16
Q

How many bonds hold an H chain and L chain together?

A

1

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17
Q

What are the two types of L chains?

A

Kappa and Lambda

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18
Q

How many amino acids are found in a domain?

A

About 110

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19
Q

How many domains does an H chain have?

A

3

20
Q

How many domains does and L chain have?

A

1

21
Q

How many domains are found in IgG, IgA, and IgD?

A

3

22
Q

How many domains are found in IgM and IgE?

A

4

23
Q

Which isotypes do not have a hinge?

A

IgE and IgM

24
Q

What is the single effector function of B cells?

A

To produce antibodies

25
Q

Which isotypes have 4 Ch domains?

A

IgM and IgE

26
Q

Which isotypes have 3 constant domains?

A

IgA, IgD, and IgG

27
Q

Domains have about how many amino acids?

A

110

28
Q

Which portion of the antibody determines its function?

A

The constant region

29
Q

What is the ratio in weight of heavy chain to light chain?

A

2:1

30
Q

What is fab?

A

The fraction antigen binding site

31
Q

What is Fc?

A

Fraction crystallizable

32
Q

Which isotypes have the hinge present?

A

IgG, IgA, and IgD

33
Q

Which enzyme must antibodies be treated with to make Fab and Fc?

A

Papain

34
Q

True or False. Fab can retain the ability to mind antigen.

A

True

35
Q

Which region contains the hinge? Fab or Fc.

A

Fc

36
Q

What is the function of the Fc region?

A

Opsonization and deliver the antibody to specific anatomical sights

37
Q

Which enzyme is used to make F(ab’)2?

A

Pepsin

38
Q

What pieces are found in F(ab’)2?

A

Both Fab regions and the hinge

39
Q

Where is the hinge found?

A

Between Ch1 and Ch2

40
Q

Which residues primarily makeup the hinge region?

A

Pro, Ser, and Thr

41
Q

How many epitopes does the hinge allow Fab to bind?

A

2

42
Q

Which isotypes are associated with the J chain?

A

IgA and IgM

43
Q

Which form of IgM does not have a J chain?

A

Hexameric IgM

44
Q

How many J chains are found per antibody polymer?

A

1

45
Q

What is transcytosis?

A

Transport of antibodies from the basal side of the epithelium to the mucosal surface

46
Q

Papain digestion results in how many pieces?

A

3

47
Q

Pepsin digestion results in how many pieces?

A

1 the F(ab’)2

Immunology (4 decks)

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