Gram positive bacilli Flashcards
Bacillus anthracis common symptoms
- Eschar
2.
Bacillus anthracis description
Large rods in chains
Bacillus anthracis capsule
Made of protein
Bacillus anthracis use of oxygen
Obligate aerobe
Does Bacillus anthracis have spores
YESSSSSSSSSSS
Bacillus anthracis toxins
- Edema factor
- Lethal factor
Edema factor in Bacillus anthracis
Functions as an adenylate cyclase
Lethal factor in Bacillus anthracis
Endotoxin that acts as a protease of MAP kinase
Causes tissue necrosis in a host cell
Wool sorters disease
Pulmonary anthrax
Pulmonary anthrax complications
Pulmonary hemorrhage (almost 100% mortality)
Widened mediastinum
Bacillus anthracis treatment
Fluroquinolones
Doxycycline
Bacillus cereus facts
Spore forming and aerobic
Bacillus cereus manifestations
Food poisoning from reheating rice
Clostridium tetani and oxygen
Obligate anaerobe
Clostridium tetani and spores
Spore forming
Where is Clostridium tetani found
Soil
How does the Clostridium tetani enter the body
Cuts by rusty nails or soil
Clostridium tetani symptoms
Spastic paralysis
Evil smile
Lock jaw
Opisthions- extension and arching of the back
Clostridium tetani pathogenesis
- Puncture wound
- Bacterium vegetates
- Produces tetanus toxin
- Toxin travels retrograde through spinal cord (motor neurons)
- Toxin acts as a protease
- Protease cuts SNARE proteins
- Without SNARE, GABA and glycine are inhibited
Renshaw cells
Sense activity of nearby neurons
Clostridium tetani vaccine
Toxoid vaccine- toxin conjugated to a protein to increase immunogenicity
