Gram negative cocci Flashcards
Neisseria metabolism
Glucose
Is Neisseria oxidase positive
Yes
Host defense mechanism against Neisseria
Membrane attack complex
Virulence factors of Neisseria
Pilli
IgA protease (inactivate IgA)
LOS (proinflammatory)
Opa proteins
Opa proteins
Mediate tight interactions with host cells
Neisseria meningitidis fermentation
Glucose and maltose
Neisseria meningitidis vaccines
Available for all types of Neisseria meningitidis
LOS (lipooligosaccharide)
Potent stimulator of the immune system
Neisseria meningitidis outbreaks
Close quarters (military camps and college dorms)
Neisseria meningitidis pathogenesis
- Make way to nasopharynx
- Travel to bloodstream
- LOS causes an inflammatory response
- Vascular injury
- Causes hypovolemia and shock
- Vasocontraction and thrombocytopenia (petechial rash)
- Crazy imbalance of clotting and bleeding (DIC)
Neisseria meningitidis causes
Protein C dysfunction
Waterhouse Frerichsen syndrome
Pressure in adrenals goes way up
Adrenal insufficiency
Neisseria meningitidis immune complex sequelae
Pericarditis
Arthritis
Signs and symptoms of Neisseria meningitidis
Fever
Malaise
Muscle aches (very intense)
Sore throat
Petechial rash
LP of Neisseria meningitidis
High protein
Low glucose
High white cells
Gram negative diplococci
Neisseria meningitidis diagnosis
Lab workup of CSF
Neisseria meningitidis treatment
3rd gen cephalosporin
Penicillin
Neisseria meningitidis close contact
Rifampin for post exposure prophalaxis
Quadrivalent vaccine
Protects against 4 strains of Neisseria meningitidis
Is neisseria gonorrhoeae encapsulated?
NO
Neisseria gonorrhoeae common disease
STIs
Clinical features of Neisseria gonorrhoeae
Inflammation of the genitalia
Fitz-Hugh-Curtis syndrome
Inflammation of the peritoneum
Triad of symptoms of Neisseria gonorrhoeae
Polyarthralgia
Tenosynovitis
Dermatitis
Diagnosis of Neisseria gonorrhoeae
Nucleic acid amplification testing
Treatment of Neisseria gonorrhoeae
Single intramuscular does of ceftriaxone
Doxycycline or macrolide
What is Neisseria gonorrhoeae usually coinfected with
Chlamidya
