Gradual loss of vision Flashcards
causes of gradual loss of vision
cataract, macular degeneration, glaucoma, diabetic retinopathy, hypertension, optic atrophy, slow retinal detachment
what is the main cause of blindness
age related macular degeneration
what part of the vision is lost in age related macular degeneration
central vision (peripheral is maintained)
dry age related macular degeneration
mainly drusen and degenerative changes at macula. slow progression
wet age related macular degeneration
new vessels grow from choroid into retina and leak. deteriorates quickly
features age related macular degeneration
progressive gradual loss of central vision- difficulty reading and recognising distant objects. peripheral vision maintained so can navigate. pupil reactions normal
what can wet age related macular degeneration present like
vision deteriorates quickly. distorted images- straight lines wavy.
when are drusen usually first deposited
after age 45 years, but asymptomatic then
what investigation can be done age related macular degeneration if suspecting choroidal neovascularisation
fundus fluorescin angiogram. optical coherence tomography (OCT)
management age related macular degeneration
intravitreal VEGF inhibitors- bevacizumab and ranibizumab (wet); laser photocoagulation(wet); intravitrealsteroids; antioxidants and vitamins
pathogenesis open angle glaucoma
aqueous humour drains through trabecular meshwork in angle between cornea and iris. over time it undergoes morphological change. rise in IOP transmitted to optic disc where nerve fibre damage occurs
risk factors open angle glaucoma
genetic, increasing age, DM, myopia, black race, thin cornea
features open angle glaucoma
no symptoms until so advanced that central vision is threatened, no headache, eye pain, loss acuity
signs open angle glaucoma
increased IOP, optic disc cupping, peripheral visual field loss
optic disc exam open angle glaucoma
rim becomes pale and cup enlarges. cup:disc ratio
what cup:disc ratio suggests glaucoma
0.6. also asymmetry between the eyes of 0.2 is significant. (normal 0.4-0.7)
how to examine optic disc
stereoscopic viewing through a dilated pupil. OCT optical coherence tomography
visual field defect open angle glaucoma
central scotoma
treatment open angle glaucoma
prostaglandin analogues- latanoprost, travoprost- incr aqueous outflow through uveoscleral route rather than trabecular meshwork; B blockers to reduce production humour- timolol, betaxolol; alpha adrenergic agonists- brimonidine; carbonic anhydrase inhibitors; miotics- pilocarpine; sympathomimetics