GPCR Signaling Flashcards
1
Q
Gs
A
Ligand: histamine, epinephrine on BETA adrenergic receptor Stimulates adenylate cyclase Increases cAMP Activates pka phosphorylates reactions
2
Q
Gi
A
Ligand: dopamine on D2, Epinephrine/noreepinephrine on ALPHA Adrenergic receptor inhibits adenylate cyclase does not generate cAMP does not activate pka dephosphorylates reactions
3
Q
Gt
A
Ligand: light
conformation change
stimulates gGMP phosphodiesterase
breaks gGMP
4
Q
Gq
A
ligand: acetylcholine on muscarninc acetylcholine M3receptor
Activates: phospholipase C
breaks into DAG & PIP2
DAG–> activates PKC–> phospohorylate multiple targets
PIP2–> IP300> opens ER channels–>releases calcium–> acts on calcium sensored proteins
5
Q
Cholrea
A
acts on Gs consistently activates adenylate cyclase generates too much cAMP activates pka chloride leaves, sodium leaves, water leaves--> diharrea
6
Q
pertusis
A
acts on G1 doesn't allow for inhibition of adenylate cyclase generates too much cAMP activates pka mucous membranes--> whooping cough
