DNA Repair Mechanisms Flashcards
Polymerase proofreading
DNA polyermase while replicating has proofreading abilities to check
Direct Repair
repairs dimers by using DNA photolyase to fix pyrimidine dimer to break bond and absorb light
OR: using methylguanine methyltrasnferase to more the methyl from G–C when it doesn’t belong there
Base excision repair
replaces the wrong base, for non-ioninzing/non-distorting repairs uusing DNA Glycosylase
nucleotide exision repair
changes the entire nucleotide in distorting change using the NER complex
mismatch
fixes the mismatched pair in teh daughter cell, this is dangerous due to the misfolding of the DNA causing a deformity
recombination
breaks the double strand or inner strand caued by crosslinking by ionizing radiation
non-homologous end joining
cuts cross linking out and just puts them back together, could be missing DNA
homologous end joining
you have the template to fix and fill in
transcription coupled repair
will see RNA stalling and allow it to continue on