GP & PH Flashcards
In what patients is QRISK2 not used/ Contrindicated
Those who have had a CV event
Type 1 diabetes
CKD
Which patient groups are will QRISK2 underestimate CVE risk
HIV Recent stop smokers Mental health problems Antipsychotics (change blood profile) Autoimmune disorders
What is the blood results you would see in acute pancreatitis
Raised amylase
List common causes for raised amylase
Acute pancreatitis
Gallstones
Alcohol
Scorpion bites
List some differentials for a recurrent cough with mucus and first line investigations
URT: Post nasal drip - recent illness, allergies?
LRT: infection, SOB, fever.
First line investigations: temperature, vitals, look in nose - any redness/ swelling that suggests allergies
Chest exam - can you hear anything in lungs suggesting infection
Bloods - infection screen (FBC, CRP)
What is the management of seasonal allergic rhinitis
Mild-moderate
1.Advice on avoiding allergens
2.PRN nasal antihistamine or oral non-sedating antihistamine citirizine
Moderate-severe (or above has failed)
1.Regular nasal steroid during periods of exposure (nb, maximal affects after 2 weeks, so need to keep going with it). Nasal drops if obstruction.
2.Combined therapy - antihistamine & steroid
Fluticasone and azelastine
(nasal spray longterm, nasal steroid drops during exposure to allergen, may need to be on these long term if its a house dustmite allergy)
+advice on allergen avoidance
What is the management of post-nasal drip
If the cause is allergic rhinitis - as per management for this - nasal spray antihistamine or steroid.
What is the difference between bronchiolitis and viral induced wheeze, what questions in a history would differentiate thess
Bronciolitis - usually <2 years. Corzyal symptoms, active illness. Acute wheeze. Fine crackles.
Viral induced wheeze - usually >2 years, post infections (recent illness but not active - failure of lungs to settle down after viral illness). Gradual wheeze. No fine crackles.
List some of the differential symptoms between bronchiolitis and viral induced wheeze
Age Corzyal symptoms present Are the currently sick Acute or gradual onset Fine crackles on auscultation
What is the management of POTTS
Beta blocker for tachycardia - bisoprolol
Steroid for hypotension - fludorcortisone
Which beta blocker is beta-1 selective
Which beta blocker is not beta-1 or beta-2 selective
Bisoprolol, atenolol
Propanalol - beta 1 and 2
What is the management of constipation in children in general practice
1.Lactulose (2.5 - 20 mL, depending on age) twice a day. NB adult lowest dose is 15 mL
May take up to 48 hours to act
Stool softener
2.Refer for stronger laxitives - movicol
3.Disimpaction movicol regime
List the different types of laxatives that can be used in children and adults
Osmotic: increase water in the bowel ‘stool softeners’ - Lactulose (sugar not absorbed in small bowel), Macrogol (Movicol),
Bowel stimulants: Sodium picosulfate,
Bisacodyl, Senna
What assessment do you need to do in children with constipation
What red flags need to be ruled out?
Ask about diet, especially milk
When did they pass their first stool >48 hrs?
Check lower limb reflexes
Is it associated with any foods - coaeliacs / allergies
Think about CF - Pale stools, persistent wet cough
Red flags - 1)absent/ reduced lower limb reflexes - any signs of cord compression 2) delayed meconium passage 3) persistent wet cough (CF)
What is the blood sugar range in a non diabetic - fasting, and non-fasting
Fasting <5.5
Non-fasting <7.8
What are diagnostic blood sugars for diabetes, fasting and non-fasting
Fasting >7
Non-fasting >11.1
What criteria is used to diagnose familial hypercholesterolaemia
Simon Broome criteria
What reduction in LDL do you look for after 3 months of being on a statin
40% reduction
What are the indications for prescribing a statin in non-FHC
QRISK2 >10%
What are the indications for prescribing a statin in FHC
Everyone with FHC should be on lipid-modifying therapy unless it is contraindicated. But, different statin used for primary (atorvostatin) vs secondary prevention.
CI: active hepatic disease, pregnancy
What is the recommended cholesterol range in UK
5 mmol/L and below
How is familial hypercholesterolaemia diagnosed
What is the chance of inheriting it from a parent with confirmed diagnosis
Blood test - look at cholesterol level
Refer to specialist for gene testing to confirm
50/50 chance of getting it in a first degree relative
What dietary advice would you give somebody with familial hypercholestrolaemia
Lower intake of high cholesterol foods: fats, diary, meats
Replace with vegetables, pulses, nuts - Mediterranean diet
What bloods should be done before starting someone on a statin
Full lipid profile Creatinine Kinase LFTs U&E HbA1c TFT (hypo can cause dyslipidaemia)
What target HDL reduction would you want in someone with familial hypercholesterolaemia
50%
What are some of the common side effects of statins
muscle and joint pain
nosebleeds
sore throat
a runny or blocked nose (non-allergic rhinitis)
headache
feeling sick
problems with the digestive system, such as constipation, diarrhoea, indigestion or flatulence
increased blood sugar level (hyperglycaemia)
an increased risk of diabetes
What is the mechanism of action of statins
Statins act by competitively inhibiting HMG-CoA reductase, the first and key rate-limiting enzyme of the cholesterol biosynthetic pathway.
They block the metabolism of lipids to cholesterol.
You have a patient who is newly diagnosed with hypertension after home ambulatory BP monitoring. What investigations do you want to do to confirm/ rule out end organ damage,
ECG - LV hypertrophy U&E - kidney function FBC - polycythaemia LFT - for baseline Lipid profile HbA1c - diabetes
What are the treatment options for menopause for somebody with a uterus
1. HRT: Coil (mirena) + oestrogen patch Combined (progesterone + oestrogen) HRT Cyclical - bleed Continuous - no bleed 2.SSRI, Clonidine (both are vasoconstrictors)
Mood symptoms: HRT/ CBT Anxiety: CBT Decreased libido: HRT/ testosterone gel Muscular symptoms: HRT Vasomotor symptoms: SSRI/ clonidine
What do you have to consider in a patient who has a uterus when prescribing HRT
Prescribing combined HRT with progesterone to protect the endometrium
What HRT can you offer to someone for menopausal symptoms who has no uterus
Oestrogen only HRT - do not need to worry about endometrial protection via progesterone
What are the contraindications for HRT
Active breast cancer Active or recent CVD (angina, MI) Current VTE or thrombophlebitis or Hx of recurrent VTE Undiagnosed vaginal bleeding (?Endo Ca) Untreated endometrial hyperplasia Liver disease, abnormal LFTs
In a patient with a BMI >30, what HRT would you offer for menopausal symptoms
Transdermal patch, because they are at higher risk of VTE, patch lowers any increased risk from oestrogen
What assessment should you do before starting someone on HRT
CVD risk assessment (bc CI in active CVD)
Check CI / BMI
Discuss risks with Breast Ca, smoking, VTE, ovarian Ca
What tests would you do to confirm if someone has gone through menopause
FSH - will be high if no longer ovulating
When should H Pylori be suspected and investigation
Complaint of epigastric pain
How is H pylori investigated
Stool sample
How are H Pylori sensitivies taken
Gastric biopsy
What are common side effects of PPIs, how can these be managed
Rebound hyperacidity - tapering withdrawal of PPI
Hypomagnesemia - bc of reduced Mg absorption in gut
What differentials should you consider in someone presenting with burning chest pain after eating, and at night
GORD Barratts oesophagus Oesophagitis Malignancy Systemic sclerosis
What red flags should you ask about in someone presenting with burning chest pain that is related to eating (gastric chest pain)
1.dyphagia + ANY ALARM sign or persistent symptoms Anaemia (unexplained) Loss of weight Anorexia Recent onset Melena, haematemasis
What red flag should you ask in anyone presenting with epigastric pain (dyspepsia)
If they have any difficulty swallowing
+ ALARM signs
What is the management of GORD
1.Lifestyle changes - alcohol, caffeine OTC antacids (Mg trisilicate) - review at 4 weeks 2.PPI or H2 blocker for 4 weeks 3. Endoscopy (hernia)
List some differentials for gastric chest pain
GORD
Hiatus hernia
Oesophagitis
Malignancy - oesophageal
What diet & lifestyle advice would you give to someone with GORD as first line management
Weight loss, smoking cessation, small, regular meals, reduce hot drinks, alcohol, citrus fruits, caffeine, chocolate
Avoid eating <3 hrs before bed
List some differentials for epigastric pain (dyspepsia)
Duodenal/ gastric ulcers Duodenitis Gastric malignancy Gastritis Oesophagitis / GORD
What is the management of dyspepsia (epigastric pain)
1.Over 55 years OR dyphagia + ANY ALARM sign or persistent symptoms - urgent referral
2. Lifestyle / drug modifications (NSAIDs, Alcohol).
OTC antacids
3. H Pylori
4. PPIs/ H2
5. Referral - endoscopy
What is the monitoring time on bisphosphonates
6 months
What is the management of osteoarthritis
Exercises
Movement/ mobilse joint
Pain relief
What is the management of osteoperosis
Bisphosphonates - inhibit osteoclasts
Calcium and vitamin D
Monitor bloods every 6 months
What are the different levels of PVD
Asymptomatic
Intermittent claudication
Ischamic rest pain
Critical ischamia - ulceration/ gangrene
What examination should you do on someone with PVD
Feel for foot pulses Temperature Colour Sensation 6Ps
List some causes of venous insufficiency
blood clots. varicose veins. obesity. pregnancy. smoking. cancer. muscle weakness, leg injury, or trauma.
What are the most common areas for atherosclerosis in PVD
Buttocks
Calves
Penis
Coronaries
What is the protocol for GTN spray and chest pain
x2 sprays under the tongue, if not gone after 15 minutes call for an ambulance
What is included in a postnatal check for the baby
Eyes - red reflex, fix and follow Hearing - startle to noise? Palate - tongue tie/ cleft palate Head control- should have by 6 weeks Palmar creases - DS Heart - murmurs Chest - vesicular breathing Hips Testes Femoral pulses Anus
What are your differentials for a patient complaining of being ‘dizzy’
Brain - any focal neurology, balance
Heart - arrhythmia, valve (age), HTN, palpitations
ENT - labrynthitis, nausea, fever, recent illness
Medication - any new meds?
What is the criteria for referral with raised PSA
> 3 on 2 separate occasions
20 immediate referral
Double PSA if on alpha blocker
If have UTI, repeat as this can raise it
What can raise a PSA level
UTI
List some red flag features of critical ischemia
Pain at rest at night - alleviated by hanging leg over bed
Pale, cold, pulseless, paraesthesia
What is the management of sleep apnea
cPAP
What are some common symptoms of sleep apnea
Headache
Hypertension
Bc, heart is having to work harder and brain underperfused
Outline the different antidepressants
SSRIs
SNRI - mirtazepine, trazadone, venlafaxine
What are the side effects of mirtazepine
Drowsiness
What are the side effects of trazadone
Weight gain
In what groups would you treat an asymptomatic UTI
Pregnancy
Children
<3 months <3 years?
Men <65 years
What should you always check in a patient presenting with memory loss/ confusion who is elderly
Medication review - any medicines that could cause this
What are screening bloods for memory loss
FBC - Haematinics
Calcium
Folic acid
Outline the management of gout
Allopurinol - preventer
Colchicine - for acute episode
What blood test do you need to do before starting someone on antifungals
LFTs
What do you prescribe for folliculitis
Doxycycline
How would you assess a testicular lump
Smooth/ hard
Can you get all the way around it
It is tethered
is it in testes or epidydimis
List some differentials for testicular lumps
Epidydimal cyst Hydrocele Varocele Spermatocele Orchitis
Give some differentials for light headedness
Anaemia
Valves - cardio
Postural hypotension
What should you look for when examing a child with undescended testes
Can you pull the testes down if they are not in the scrotum
If no, need to refer to paeds surgeons
How would you assess the stability of a joint in someone with ?osteoarthritis
Ask if the joint has given way on them
Have they had any trips/ falls bc of joint
What red flag should you ask about in an osteoarthritis hsitory
Does the pain wake you up at night - this may be a sign of malignancy - its also an indication for surgical referral
OA pain may stop them going to sleep but shouldnt wake up with pain
Functional assessment - ADL - also indication for referral if cant carry out activities of daily living
What should you assess in an OA history
Pain
Functional assessment - can they walk, can they do ADL - this will affect referral
What is the community management of OA, when would you refer
Conservative - exercise, activity, muscle strength, occupational therapy, walking aids, weight loss, footwear
Pharmacological - pain relief. Paracetamol, NSAID (caution - gastro protection), dermal patches (bupronorphine), intra-atricular steroid injections.
Surgical management (referral).
What would you look for on examination of OA joint
ROM - compare joints
Pain - compare joints
Bony swelling
Tender
What are the main differences in rheumatoid and OA on presentation
Joints involved - symmetrical vs non-symm
Soft tissue involvement - hot, swollen RA
Bony swelling - OA
Extra-articular involvement - RA
Weight baring joint - OA
Pattern of pain - worse at night/ waking - RA
Improves with joint movement - RA
Joint stability - gives way - OA
List some activities of daily living that you should ask about in an OA history
Walking Can they get up and down stairs Shopping Eating Bathing Dressing Toileting (being able to get on and off the toilet)
In a patient who presents with anaemia & melena, what non-cancer causes of bleeding should you look for on examination
Haemorrhoids
Anal fissure
Anything external around anus that could be causing bleed
List some red flags for bowel cancer
Recent change in bowel habit - constipation or diarrhoea Melena, haematemsis Unexplained anaemia Weight loss Lethargy Fatigue Age >60 years (may be 55 years)
List some differentials for recent change in bowel habit
IBD IBS - ask about at night symptoms Diverticulosis (age - >60 years) Coeliacs - any recent dietary changes Malignancy Infection - recent travel Biliary disease Liver disease - decompensated
What is the management for genital herpes
Acyclovir
5 day course, if get more lesions 5 days more
If no new lesions, stop
What is pica and what is it sign of
Craving cold things, like ice, of no nutritional value
Sign of iron deficiency anaemia
What causes should you consider in someone with iron deficiency anaemia
Dietary - poor intake (supplements)
Bleeding - most likely in gut
How many virus can under 5s have per year
up to 13
What conditions need to be met for somebody to have ‘capacity’
They understand information about the decision
They can remember (retain) the information
They can use the information to make a decision (can they weigh up the consequences of the decision)
They can communicate their decision
What is the next step is someone doesnt have capacity
You should make a ‘best interests’ decision
Should involve family, carers, mental capacity advocate
How cab you determine if somebody qualifies for deprivation of liberty safeguards assessment
Are they free to leave
Are they under continuous observation or control
Do they lack capacity to consent
Are they confined to a restricted place for a non-negligible period of time
When should DOLS be considered
Someone who lacks capacity who has they liberty deprived for a period of time
Eg. someone who has a head injury who is admitted for investigations - not DOLS - this is not a ‘period of time’ it is part of routine investigations
Someone who is kept in a particular area and cannot leave, and they cannot consent (eg in a nursing home) for a long period time should have DOLS
What is required for DOLS
Must be necessary and in patients best interest
Harm prevention via DOL must be proportional to that harm
What is a typical UTI in an adult
Non pregnant female No systemic features No loin pain/ renal angle tenderness E coli Not recurrent
What is a typical UTI in a child 3months - 16 years
Not systemically unwell Responds to abx E coli Passing urine No abdominal mass
What assessment should you do on all adults with LUTS
Pyelonephritis assessment
Sepsis assessment
Men - Prostate
Sexual health/ infections assessment
What inheritance pattern is haemochromatosis
Recessive
What inheritance pattern is wilsons disese
Recessive
What inheritance pattern is Huntingtons
Dominant
List some of the symptoms of haemochromatosis
arthralgia
Hepathomegaly
Liver signs and symptoms
More common in men than women - menstrual blood loss is protective
What is the composition of bone
Inorganic bone mineral (hydroxylapatite) and organic bone matrix (collagen and ground substance)
What is the clinical cut off for hypertension
135/85 - 24 hours ambulatory, or 1 week of home readings
140/90 in clinic
What is the HTN treatment goal for someone 1) without diabetes, 2) with diabetes, 3) >80 years
- <140/90
- 130/80
- 150/90
What secondary preventation medications should all post MI patients be on
Duel antiplatelet therapy - Aspirin, clopidogrel
Statin
Beta-blocker
ACE inhibitor
What are some common side effects of ACE inhibitors
BEK BP - hypotension Electrolytes - hyperkalaemia Kidney - acute renal failure Cough Rash
List an urinary anticholinergic and alpha blocker
Oxybutynin - anticholinergic
Tamsulosin - alpha blocker
What is the difference between chronotrope and inotrope
chronotrope increases HR
inotrope increases contractility
Which beta receptors are predominantly in the heart
Beta 1 - bisoprolol
What is the action of ACE inhibitors and S/Es, when are the contraindicated
Peripheral vasodilator
S/E: BEK
C/I: women of child bearing age. pregnancy, sometimes pre-existing renal disease, if causing HTN
What is the action of CCB and S/E, when are the contraindicated
Peripheral vasoconstriction by L type calcium channel inhibition. Two types - act peripherally or centrall.
Peripheral: flushing, headaches, oedema, palpitations
Central: bradycardia, worsening HF
C/I in heart failure
What are the different types of diuretics and their side effects
Loop - furosemide, bumetadine
Thiadize - bendroflumethazide, indapamind (erectile dysfunction)
K sparing - aldosterone
SE: The ‘E’s: empty, electrolytes, erection
Electrolytes - hyper/hypokalaemia, hyponatraemia, hypomg, hypocalacaemia.
What is the management of heart failure
Diuretics - treat congestion ACE inhibitor plus BB \+Spironolactone \+Digoxin \+Vasodilator - nitrates and hydralazine
Sacubitril + ARB can be used to prevent MIs in those with HF
What is the pharmacological management of angina
Primary prevention: antiplatelets and statin for CVD risk Secondary prevention: 1st line: BB or CCB (+gtn) 2nd line: add on vasodilator - ivabridine, nicorondil
What is the management of Acute coronary syndromes
ST elevation:
Antiplatelets - aspirin 300 mg loading, then ticagralor 180 mg
Pain relief - morphine
Oxygen, nitrates
Anticoagulate - AF risk
Beta blockers - rate stabaliser
>12 hrs - refer for PCI, if no PCI consider thrombolysis
Non ST elevation:
Antiplatelets- aspirin 300 mg
Analgesia - morphine
Nitrates - GTN
Measure troponin - if low conservative strategy
Raised - anticoagulate, second antiplatelet, IV nitrate, BB
What symptoms differentiate stable angina, unstable angina and MI
Stable angina - predictable, exertional, non persistent
Unstable angina (NSTEMI) - unpredictable, rest pain, non-persistent
ACS (STEMI) - unpredictable, rest pain, persistent
What is the triad of angina
Chest pain
Brought on by exersion
Alleviated by rest
What is the primary prevention of angina
Diet - lower low density fat intake, fruits vegetables Exercise Manage HTN Lipids - statin Diabetes management Smoking/ alcohol