GP Flashcards

1
Q

LUTS symptoms (9)

A
  • hesitancy
    -weak flow
  • urgency
  • frequency
  • intermittency
  • straining
    -terminal dribbling
  • incomplete emptying
  • nocturia
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2
Q

How should a LUTS/BPH pt be assessed? (5)

A
  • urine dipstick (r/o infection etc)
  • U+Es (esp if chronic retention suspected)
  • PSA (pt preference, recommended if sx are mostly obstructive)
  • urinary frequency volume chart (3 days fluid intake and output)
  • DRE
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3
Q

What can raise PSA? (6)

A
  • prostate cancer
  • BPH
  • prostatitis
  • UTI
  • vigorous exercise (esp cycling)
  • recent ejaculation/prostate stimulation
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4
Q

How can benign and cancerous prostates differ on exam?

A

benign → smooth, symmetrical, slightly soft, maintained central sulcus
cancerous → firm/hard, asymmetrical, craggy/irregular, loss of central sulcus

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5
Q

Medical mx of BPH

A
  • alpha-blockers (e.g. tamsulosin, relaxes smooth muscle and improves sx)
  • 5-alpha reductase inhibitors (e.g. finasteride, gradually reduces prostate size) *tends to only be indicated if enlargement is significant/high risk of progression

(however combo therapy more and more common - “moderate to severe voiding sx”)

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6
Q

What is the most common surgical tx of BPH?

A

transurethral resection of the prostate (TURP)

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7
Q

LOSS

What are the 4 key x-ray changes seen in osteoarthritis?

A
  • Loss of joint space
  • Osteophytes
  • Subarticular sclerosis (incr density of bone along joint line)
  • Subchondral cysts (fluid filled holes in bone)
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8
Q

What are the most commonly affected joint in osteoarthritis? (6)

A
  • hips
  • knees
  • DIP joints hands
  • CMC joint (base of thumb)
  • lumbar spine
  • cervical spine (cervical spondylosis)
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9
Q

What are the typical features of an osteoarthritis presentation? (6)

A
  • joint pain and stiffness
  • sx worsen with activity and by the end of the day
  • bulky, bony enlargement of the joints
  • restricted ROM
  • crepitus on movement
  • effusions around joint
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10
Q

What are the hand signs specific to osteoarthritis? (3)

A
  • bouchard’s nodes (PIP)
  • heberden’s nodes (DIP)
    B comes before H, proximal before distal
  • squaring at the base of the thumb (CMC)
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11
Q

How is osteoarthritis dx according to NICE guidelines?

A

without ix if pt >45 and has typical pain associated with activity and NO morning stiffness (or lasts <30mins)

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12
Q

NG osteoarthritis mx (pharmacological and non)

A

non-pharmacological → therapeutic exercise, WL, OT (to support ADLs)

pharmacological → topical NSAIDs (1st line for knee), oral NSAIDs (+PPI), weak opiates/paracetamol (short and infrequent use), intra-articular steroid injections (temporary sx relief - up to 10wks)

joint replacement in severe cases (hip, knee esp)

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13
Q

What is the typical presentation of trigeminal neuralgia?

A

attack of facial pain (shooting, electric like) of sudden onset, lasting seconds to hours triggered by touch (eating, shaving, cold)

*can affect any combo of the branches of the trigeminal nerve (opthalmic, maxillary, mandibular)

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14
Q

What can cause trigeminal neuralgia/is often associated with it? (2)

A

majority are idiopathic

  • compression of trigeminal roots by tumours/vascular problems
  • more common in pts with MS
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15
Q

What is first line for trigeminal neuralgia?

A

carbemazepine

failure to respond or atypical features = prompt neuro referral

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16
Q

What type of hypersensitivity is allergic contact dermatitis?

A

Type IV - delayed/cell mediated hypersensitivity (pts often have pre-existing atopy)

first contact does not result in allergy, can take months/years of contact

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17
Q

What are the two main types of contact dermatitis?

A

irritant → a common, non-allergic reaction due to weak acids/alkalis (e.g. detergents, cement) - often seen on hands and mostly erythema

allergic → type IV hypersensitivity, uncommon and often seen on head follow hair dye - tends to present as acute weeping eczema

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18
Q

What kind of dermatological presentation is nappy rash?

A

contact dermatitis (caused by friction between skin and nappy and contact with urine/faeces - hence why spares folds)

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19
Q

What infections can occur where there is nappy rash?

A
  • fungal (candida)
  • bacterial (staph, strep)

due to skin breakdown and warm moist environment

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20
Q

Treatment for fungal infection of nappy rash

A

clotrimazole or miconazole

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21
Q

Treatment for bacterial infection of nappy rash

A

fusidic acid cream or oral flucloxacillin

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22
Q

What layers of the bowel does diverticular disease involve?

A

herniation of the colonic mucosa through the muscle wall of the colon (rectum is usually spared due to lack of taenia coli - vessels that pierce the muscle to supply the mucosa)

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23
Q

What are symptoms of diverticular disease?

A
  • altered bowel habit
  • rectal bleeding
  • abdo pain (often LIF)
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24
Q

What are potential complications of diverticular disease? (5)

A
  • diverticulitis
  • haemorrhage
  • fistula development
  • perforation and faecal peritonitis
  • perforation and abscess development
25
Risk factors for diverticulosis (4)
- increased age (wear and tear) - low fibre diets - obesity - NSAID use (esp haemorrhage)
26
Management of diverticulosis (3)
- increased fibre in diet - bulk-forming laxatives (isphagula husk) - surgery if severe *AVOID stimulant laxatives (senna)*
27
Presentation of acute diverticulitis (7)
- LIF pain/tenderness - fever - diarrhoea - nausea/vomiting - rectal bleeding - palpable abdo masses (is abscess formed) - raised CRP/WBC
28
Management of uncomplicated acute diverticulitis (4)
- oral co-amoxiclav (625mg TDS for 5 days, then review) - analgesia (avoid NSAIDs/opiates) - only clear liquids until sx improve - follow up in 2 days
29
What is the most common cause of bacterial tonsillitis?
group A streptococcus (strep pyogenes) *second most common = strep pneumoniae
30
How is bacterial tonsillitis treated? (+ if allergic)
penicillin V (phenoxymethylpenicillin) 500mg QDS for 5-10 days true penicillin allergy = clarithromycin
31
What complication is important to safety net when treating tonsillitis?
peritonsillar abscess (quinsy) → unilateral severe throat pain, uvula deviation to unaffected side, trismus, reduced neck mobility
32
Which points are key in both Centor criteria and FeverPAIN score for determining abx use in tonsillitis?
- fever - purulence/tonsillar exudates - absence of coryzal sx - lymphadenopathy
33
When do NICE recommend considering tonsillectomy?
- sore throats due to tonsillitis (i.e. not recurrent URTIs) - 7 episodes per year for one year, 5 eps for 2yrs or 3 eps for 3yrs - episodes of sore throat are disabling and prevent normal functioning *must meet all criteria*
34
What causes atrophic vaginitis?
GU syndrome of menopause - dryness and atrophy of the vaginal mucosa related to a lack of oestrogen
35
how does atrophic vaginitis present? (4)
- itching - dryness - dyspareunia - bleeding (due to localised inflammation)
36
what other dx are associated with atrophic vaginitis?
- recurrent UTIs - stress incontinence - pelvic organ prolapse
37
TX options for atrophic vaginitis (2)
- vaginal emollients/lubricants (helps dryness sx) - topical oestrogen (cream, pessaries, tablets) *similar CIs to systemic HRT*
38
What causes Parkinson's disease?
progressive reduction in dopamine in the basal ganglia leading to disorders of movement
39
Is Parkinson's typically symmetrical or asymmetrical?
asymmetrical
40
What is the classic triad of Parkinson's?
1. resting tremor (pill-rolling) 2. rigidity (cogwheel) 3. bradykinesia (slowness of movement)
41
How can bradykinesia present in Parkinson's? (4)
- micrographia - shuffling gait - difficulty initiating movement - hypomimia
42
What are associated features of Parkinson's? (5)
- depression - sleep disturbance/insomnia - anosmia - postural instability (incr falls risk) - cognitive impairment/memory problems
43
What phenomenon can occur re Parkinson's meds?
on-off pts feel their meds wear off and experience sx when their next dose is due
44
What are the 4 main medication options for Parkinson's?
1. levodopa (+carbidopa/benserazide to stop it being metabolised before reaches brain - combined this is co-careldopa) 2. COMT inhibitors (e.g. entacapone) 3. dopamine agonists (e.g. cabergoline) 4. monoamine oxidase-B inhibitors (selegiline, rasagiline)
45
Why is levodopa not 1st line for PD?
most effective for sx, but becomes less effective over time so tends to be reserved for when other tx aren't working
46
What is the main side effect of levodopa?
dyskinesia (anormal movements) such as dystonia, chorea, athetosis
47
How is amantadine used in PD?
may be used to manage dyskinesia associated with levodopa
48
What is at risk if PD meds aren't taken/properly absorbed (e.g. with gastroenteritis) - especially levodopa?
acute akinesia or neuroleptic malignant syndrome - caused by abrupt drop in dopamine levels
49
What class of medications poses a risk in PD pts?
antipsychotics (esp 1st generation) - they block dopamine receptors in the brain and as these are already damaged in PD this leads to an acute worsening of motor sx
50
Which bacteria most commonly cause UTIs? (3)
- Escherichia coli - Klebsiella pneumoniae - enterococci
51
What features suggest pyelonephritis not UTI? (4)
- fever - loin/back pain - nausea/vomiting - renal angle tenderness OE
52
Is leukocytes or nitrites the better indicator of infection in a urine dipstick?
nitrites, only leukocytes is not enough to warrant tx, but if nitrites, both, or one + RBC are present then UTI is likely
53
How can you determine the causative organism of a UTI?
MSU sent for microscopy, culture and sensitivity testing (not necessary if uncomplicated)
54
What constitutes a complicated UTI?
- pt is pregnant - UTIs are recurrent - sx aren't improved w/ abx - anatomical/functional abnormalities of the urinary tract - immunosuppressed - male - indwelling catheter
55
Management of an uncomplicated UTI
trimethoprim or nitrofurantoin for 3 days
56
What is the duration of abx for UTIs in the immunosuppressed/abnormal anatomy or impaired kidney function?
5-10 days
57
What is the duration of abx for a UTI in men/pregnant women/those with catheters?
7 days
58
When should nitrofurantoin be avoided in pregnancy?
third trimester - risk of neonatal haemolysis
59
When should trimethoprim be avoided in pregnancy?
first trimester - it is a folate antagonist so can cause congenital malformations (esp neural tube defects)